{"id":"W4366083364","doi":"10.1158/0008-5472.can-22-3004","title":"Single-Cell Spatial Analysis Identifies Regulators of Brain Tumor–Initiating Cells","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Ontario Brain Institute; Alberta Cancer Foundation; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Biglycan; Wnt signaling pathway; Biology; Versican; Extracellular matrix; Transcriptome; Cancer research; Cell biology; Phenotype; Tumor microenvironment; Brain tumor; Tumor progression; Signal transduction; Pathology; Proteoglycan; Genetics; Gene expression; Gene; Decorin; Medicine; Tumor cells","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008287871,0.0001295262,0.0002316249,0.0003741119,0.0001480735,0.00004952546,0.0003271963,0.0001104289,0.0001107932],"category_scores_gemma":[0.0001328654,0.000131802,0.0001970943,0.001309236,0.0002243888,0.000005303466,0.0001524807,0.0001802614,0.00002054118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003714193,"about_ca_system_score_gemma":0.000162882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001204059,"about_ca_topic_score_gemma":0.0009103842,"domain_scores_codex":[0.9981551,0.0001956401,0.0002990036,0.0004234584,0.000461388,0.0004654413],"domain_scores_gemma":[0.99902,0.00009427315,0.00008141773,0.0004066406,0.0002952308,0.0001024836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007060943,0.00005784924,0.00568273,0.00008687379,0.0001535599,0.000007362688,0.0001870382,0.000713292,0.9884382,0.000007145812,0.003545017,0.001050259],"study_design_scores_gemma":[0.0003293053,0.0001481798,0.0021092,0.00002200836,0.00004781827,3.793154e-7,0.0002457921,0.0004476725,0.993545,0.00004602127,0.002916486,0.0001421502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977216,0.0003678073,0.0004025145,0.0001559845,0.0002270712,0.0001569269,0.00007257288,0.0000223184,0.000873188],"genre_scores_gemma":[0.9967423,0.0001331733,0.00005946065,0.00005531139,0.0002828536,0.0000320617,0.0001153015,0.00003275779,0.002546751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005106725,"threshold_uncertainty_score":0.5374731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05748118114609737,"score_gpt":0.3396568177715605,"score_spread":0.2821756366254631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}