{"id":"W4366083752","doi":"10.1158/1535-7163.mct-22-0676","title":"Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Bundesministerium für Digitalisierung und Wirtschaftsstandort; Bundesministerium für Verkehr, Innovation und Technologie; Österreichische Forschungsförderungsgesellschaft","keywords":"Macrophage migration inhibitory factor; Monoclonal antibody; Macrophage; Cancer research; Inhibitory postsynaptic potential; Pharmacology; Chemistry; Biology; Immunology; Antibody; In vitro; Biochemistry; Cytokine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009269795,0.0003807664,0.0004579186,0.0002627679,0.0001616551,0.0000389754,0.0003275594,0.0004676131,0.001621709],"category_scores_gemma":[0.0001081768,0.0003643211,0.0002270196,0.0005760359,0.0002355326,0.0001744503,0.00006349575,0.0004059215,0.0001724878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044046,"about_ca_system_score_gemma":0.0004631719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001837605,"about_ca_topic_score_gemma":0.0000766874,"domain_scores_codex":[0.996994,0.0006987974,0.0007934444,0.0006080267,0.0003900646,0.0005156402],"domain_scores_gemma":[0.9982497,0.0001551943,0.0003781081,0.0005621197,0.0005960744,0.00005886091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002502301,0.000222825,0.0005463936,0.00004131902,0.0004819509,0.000003233974,0.001686408,0.0009436316,0.9854072,0.0002076157,0.0001231945,0.01008594],"study_design_scores_gemma":[0.003754187,0.0003055758,0.002952264,0.0000556134,0.0003993528,0.000005283896,0.0003575363,0.007012032,0.9792707,0.0002817489,0.00518344,0.0004222479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862561,0.007998631,0.002289437,0.0003816943,0.001586688,0.0009467057,0.0002358607,0.0002540752,0.00005076473],"genre_scores_gemma":[0.9979209,0.0003222053,0.0001962284,0.000553765,0.0001142584,0.0002197869,0.0003608147,0.00008891997,0.0002231262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01166475,"threshold_uncertainty_score":0.9998809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06691227969315192,"score_gpt":0.3560835251783305,"score_spread":0.2891712454851786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}