{"id":"W4366087654","doi":"10.1186/s13059-023-02924-x","title":"Metabolic independence drives gut microbial colonization and resilience in health and disease","year":2023,"lang":"en","type":"article","venue":"Genome biology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"Biotechnology and Biological Sciences Research Council; Digestive Diseases Research Core Center, University of Chicago; National Cancer Institute; National Science Foundation; National Institutes of Health; Gastro-Intestinal Research Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; University of Calgary","keywords":"Biology; Colonization; Human genetics; Independence (probability theory); Disease; Resilience (materials science); Metabolic disease; Computational biology; Evolutionary biology; Genetics; Ecology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003097006,0.0002384105,0.0002985801,0.0003284656,0.0002450564,0.0006148237,0.0001509845,0.0003499768,0.001215112],"category_scores_gemma":[0.0003966179,0.0001335934,0.0002202037,0.0002701585,0.0005733622,0.0002390082,0.000683192,0.0005074573,0.000133273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002700661,"about_ca_system_score_gemma":0.0002708141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003288089,"about_ca_topic_score_gemma":0.000529816,"domain_scores_codex":[0.9997814,0.00004408127,0.00001216046,0.00005889828,0.00003932713,0.00006407485],"domain_scores_gemma":[0.9995735,0.00005700869,0.000174713,0.00004517882,0.00002585302,0.0001237674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001201767,0.0001079059,0.05602978,0.00007617362,0.000050493,0.0001182089,0.00009143102,0.0002405603,0.9376043,0.0003101756,0.00007024487,0.004098901],"study_design_scores_gemma":[0.00004502629,0.001363533,0.8192602,0.00003148016,0.00009515118,0.0007498795,0.0005748514,0.00249931,0.1719483,0.001798215,0.001610377,0.00002354701],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998539,0.0002484824,0.0006612072,0.00007193776,0.000005899253,0.000006018302,0.0001156003,0.00001696308,0.0003348719],"genre_scores_gemma":[0.9992747,0.00009102316,0.0004270167,0.0000312604,0.000004230445,0.000006118163,0.00007760375,0.000003476635,0.00008459294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001215112,"threshold_uncertainty_score":0.004064918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009102182271776135,"score_gpt":0.275399655425444,"score_spread":0.2662974731536679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}