{"id":"W4366090856","doi":"10.3390/jcm12082888","title":"Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Medicine","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Universidade do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Medicine; Kinin; Trypanosoma cruzi; Proinflammatory cytokine; Chagas disease; Myocarditis; Heart failure; Immunology; Internal medicine; Cardiomyopathy; Blockade; Endocrinology; Pharmacology; Inflammation; Bradykinin; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235423,0.0003992336,0.0002973404,0.0002066691,0.0001511328,0.000228159,0.0001404636,0.0002673543,0.0008017072],"category_scores_gemma":[0.00005882281,0.0001355916,0.0001606956,0.00006857167,0.0002524569,0.0001851159,0.0001484756,0.0006571622,0.0001745052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048643,"about_ca_system_score_gemma":0.0001466006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004714417,"about_ca_topic_score_gemma":0.001176232,"domain_scores_codex":[0.9999167,0.00001276054,0.000009486509,0.00002010665,0.00001566094,0.00002526714],"domain_scores_gemma":[0.999953,0.00000475907,0.00001571454,0.000003877537,0.00000397645,0.00001868496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001192481,0.00002271472,0.0001337636,0.00004398046,0.000003730365,0.0000314378,0.000008251958,0.00001536923,0.9985324,0.00005373399,0.00001848383,0.00101691],"study_design_scores_gemma":[0.0001363561,0.002431379,0.02476666,0.0000474444,0.00009652523,0.0009377048,0.0001150817,0.001371908,0.9635391,0.0001434414,0.006395814,0.00001863553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99097,0.005190902,0.002227908,0.0002380952,0.00004224977,0.00003057178,0.0002290608,0.00007809042,0.0009930005],"genre_scores_gemma":[0.9920554,0.003467282,0.001936303,0.000113373,0.00002420503,0.00003319504,0.0002499212,0.00001361547,0.002106676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008017072,"threshold_uncertainty_score":0.002681971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08691623472727479,"score_gpt":0.4395760368259921,"score_spread":0.3526598020987173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}