{"id":"W4366091089","doi":"10.1101/2023.04.14.536782","title":"Myosin inhibitor reverses hypertrophic cardiomyopathy in pediatric iPSC-cardiomyocytes to mirror variant correction","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; Toronto General Hospital; University of Toronto; Ted Rogers Centre for Heart Research; Hospital for Sick Children","funders":"National Institutes of Health; Stanford Cardiovascular Institute, School of Medicine, Stanford University; Canadian Institutes of Health Research; Hospital for Sick Children; Killam Trusts; Heart and Stroke Foundation of Canada","keywords":"MYH7; Hypertrophic cardiomyopathy; Sarcomere; Myosin; MYH6; Verapamil; Internal medicine; Contractility; Muscle hypertrophy; Phenotype; ATPase; Medicine; Biology; Cardiology; Myocyte; Cell biology; Myosin light-chain kinase; Calcium; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004441745,0.0003319526,0.0003245002,0.0002350419,0.000189156,0.0002675257,0.0003848987,0.0005055558,0.004036298],"category_scores_gemma":[0.000210322,0.0001266765,0.0002821239,0.0001704733,0.0002757743,0.0001378571,0.0003047588,0.0009346482,0.001046414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351092,"about_ca_system_score_gemma":0.0002682871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002284635,"about_ca_topic_score_gemma":0.0003115376,"domain_scores_codex":[0.9997829,0.00003401511,0.00003387255,0.00004401517,0.00007465125,0.00003062226],"domain_scores_gemma":[0.999762,0.00007453259,0.00005481545,0.00003874296,0.00002293677,0.00004700505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002055303,0.00007072405,0.0005243545,0.0001163744,0.00002703099,0.0006960384,0.00004630718,0.0002570834,0.9889754,0.000840384,0.001084071,0.007156697],"study_design_scores_gemma":[0.0001207442,0.000494262,0.004133417,0.00002582042,0.00006107338,0.002494843,0.00004684995,0.001500019,0.9661487,0.0002074865,0.02475671,0.00001017565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594451,0.002973574,0.02208378,0.0009658166,0.001227571,0.0002604289,0.004119456,0.000919943,0.008004256],"genre_scores_gemma":[0.9642861,0.002441974,0.01711891,0.0004370704,0.0001876055,0.0002618453,0.003837727,0.000501634,0.01092713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004036298,"threshold_uncertainty_score":0.01350278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02301728212573269,"score_gpt":0.2410269278870363,"score_spread":0.2180096457613036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}