{"id":"W4366131934","doi":"10.1002/cbic.202300205","title":"Aldehyde‐Based Inhibitors of the Peptidoglycan <i>O</i>‐Acetylesterase Ape","year":2023,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Peptidoglycan; Acetylation; Serine; Active site; Chemistry; Biochemistry; Aldehyde; Stereochemistry; Enzyme; Bacteria; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000186262,0.0004706168,0.0002106258,0.0001567184,0.0001070017,0.0001667551,0.0003253384,0.000199982,0.0009864056],"category_scores_gemma":[0.0001181196,0.0001314726,0.0002107908,0.00008880308,0.0001515281,0.0001277425,0.0001576308,0.000413015,0.0002646778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565914,"about_ca_system_score_gemma":0.0001657354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007027783,"about_ca_topic_score_gemma":0.001487148,"domain_scores_codex":[0.9998897,0.00001869924,0.000009095242,0.00001541878,0.00003443243,0.00003266613],"domain_scores_gemma":[0.9999373,0.00001474806,0.00001357974,0.000005096443,0.00001268286,0.00001664332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002297954,0.0002033232,0.0001364715,0.0001126369,0.00002066652,0.00005509606,0.0000162388,0.0009056579,0.9932172,0.0003270502,0.0002122562,0.004563605],"study_design_scores_gemma":[0.00009123958,0.001658479,0.0007213613,0.000008356234,0.00001777763,0.0001316282,0.00000879956,0.001792068,0.9916535,0.00004680755,0.003861121,0.000008833428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715677,0.006891257,0.01231035,0.0002394666,0.0001490649,0.0002418899,0.0005092281,0.0002079393,0.007883144],"genre_scores_gemma":[0.9907435,0.002056087,0.003787882,0.00007948003,0.00001379634,0.00005382983,0.0002803396,0.00001357987,0.002971444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009864056,"threshold_uncertainty_score":0.003299832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00855876833448586,"score_gpt":0.2232174243698161,"score_spread":0.2146586560353302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}