{"id":"W4366140579","doi":"10.7326/m22-3305","title":"Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19","year":2023,"lang":"en","type":"article","venue":"Annals of Internal Medicine","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Achieve Life Sciences (Canada); McGill University Health Centre; Stantec (Canada); Impact; McMaster University","funders":"Universidade Federal de Ouro Preto; University of Toronto; University of Oxford; McMaster University; King's College London; McGill University; McGill University Health Centre; Rainwater Charitable Foundation; Pontifícia Universidade Católica de Minas Gerais; National Institute for Health and Care Research; University of Minnesota; Georgetown University","keywords":"Medicine; Budesonide; Fluvoxamine; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Asthma; Pediatrics; Internal medicine; Psychiatry; Virology; Outbreak; Disease; Fluoxetine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002600039,0.0001286086,0.0003008863,0.0000669176,0.0000208569,0.00000173063,0.0001230269,0.00006454444,0.00007847953],"category_scores_gemma":[0.0003827376,0.00007740036,0.00008350195,0.0001043363,0.0001213168,0.000002056606,0.00003091921,0.00002247459,0.000002955695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008428703,"about_ca_system_score_gemma":0.00004961518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002049595,"about_ca_topic_score_gemma":0.00003470376,"domain_scores_codex":[0.9992272,0.0000408993,0.0002197778,0.000187957,0.0001298827,0.0001942533],"domain_scores_gemma":[0.9993371,0.0001120814,0.0001254802,0.0001304427,0.000121708,0.000173161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003452153,0.0001668958,0.002933144,0.0001027199,0.0002978214,0.00004310271,0.0001474166,0.0000341319,0.9680286,0.00005548536,0.01775493,0.006983622],"study_design_scores_gemma":[0.003163657,0.02593027,0.001735925,0.00008661395,0.00005024691,0.0000231473,0.00007527364,0.00008083,0.9368325,0.0002193899,0.03169982,0.0001023393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960761,0.0002908926,0.001756334,0.001274315,0.0001159348,0.00028894,0.00006976451,0.00001170228,0.0001160077],"genre_scores_gemma":[0.997115,0.0005700874,0.0001818834,0.001147389,0.000157317,0.00005820766,0.0001010203,0.0000122653,0.0006568636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03119609,"threshold_uncertainty_score":0.3156295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08574649826669666,"score_gpt":0.4069866918969032,"score_spread":0.3212401936302066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}