{"id":"W4366140579","doi":"10.7326/m22-3305","title":"Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19","year":2023,"lang":"en","type":"article","venue":"Annals of Internal Medicine","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Achieve Life Sciences (Canada); McGill University Health Centre; Stantec (Canada); Impact; McMaster University","funders":"Universidade Federal de Ouro Preto; University of Toronto; University of Oxford; McMaster University; King's College London; McGill University; McGill University Health Centre; Rainwater Charitable Foundation; Pontifícia Universidade Católica de Minas Gerais; National Institute for Health and Care Research; University of Minnesota; Georgetown University","keywords":"Medicine; Budesonide; Fluvoxamine; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Asthma; Pediatrics; Internal medicine; Psychiatry; Virology; Outbreak; Disease; Fluoxetine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021449,0.0004078269,0.001610372,0.0003128045,0.000209572,0.0003625544,0.0004388951,0.0006895032,0.003026698],"category_scores_gemma":[0.001090685,0.0002457183,0.0009230381,0.000207918,0.0003589869,0.0002495036,0.000302638,0.0008529969,0.0002636251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003720513,"about_ca_system_score_gemma":0.0006352905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006049207,"about_ca_topic_score_gemma":0.001365884,"domain_scores_codex":[0.9994418,0.0002764628,0.00005682987,0.0000828296,0.0000717318,0.00007030682],"domain_scores_gemma":[0.9994127,0.0001585904,0.0002139539,0.00002528545,0.00002679216,0.0001627273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7721828,0.01332197,0.008815123,0.004091636,0.00207324,0.0001416956,0.00008416841,0.0006079613,0.0129344,0.0002158683,0.001248378,0.1842827],"study_design_scores_gemma":[0.7246237,0.2349823,0.03296201,0.0004137596,0.001005675,0.0002487042,0.00004533567,0.0006661453,0.001948757,0.0001548837,0.002928657,0.00002006424],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822174,0.01250734,0.0005112374,0.0005400461,0.0002541894,0.002064202,0.00028738,0.0000477821,0.001570432],"genre_scores_gemma":[0.994366,0.00230632,0.001042997,0.0003065627,0.0001703815,0.00118652,0.000156038,0.000003857274,0.0004613804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003026698,"threshold_uncertainty_score":0.01012528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08574649826669666,"score_gpt":0.4069866918969032,"score_spread":0.3212401936302066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}