{"id":"W4366169658","doi":"10.1038/s41575-023-00768-1","title":"IL-12 and IL-23 pathway inhibition in inflammatory bowel disease","year":2023,"lang":"en","type":"review","venue":"Nature Reviews Gastroenterology & Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Toronto; Western University; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Humanitas Research Hospital; KU Leuven; Lerner Research Institute, Cleveland Clinic; University of California, San Diego; University of Toronto; Amsterdam University Medical Centers; Universiteit van Amsterdam; Cleveland Clinic Foundation; Humanitas University; Cleveland Clinic","keywords":"Medicine; Inflammatory bowel disease; Inflammatory Bowel Diseases; Interleukin 23; Gastroenterology; Disease; Internal medicine; Inflammation; Interleukin 17","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00112834,0.001208717,0.002624695,0.0006098157,0.0001153889,0.00003766073,0.0004772788,0.002534094,0.00002516385],"category_scores_gemma":[0.0006565191,0.001091809,0.0009608673,0.0001943488,0.000488009,0.00001763644,0.0007297338,0.001976226,0.000282929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000135347,"about_ca_system_score_gemma":0.0004955182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002586046,"about_ca_topic_score_gemma":0.0004931716,"domain_scores_codex":[0.9925019,0.00240102,0.001903004,0.00178636,0.0002213063,0.001186473],"domain_scores_gemma":[0.9969977,0.00006492058,0.001012812,0.001299253,0.00009181115,0.0005334884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004180758,0.001133851,0.2705548,0.2208897,0.002337976,0.03414176,0.0001503543,0.000009373425,0.0002431107,0.001790037,0.05747975,0.4070885],"study_design_scores_gemma":[0.0009026324,0.0001948255,0.005314019,0.004430858,0.0005619752,0.0004693567,0.000003879697,0.000006824845,0.000002147692,0.00007306197,0.9874654,0.0005750632],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02506734,0.9706603,0.00001609849,0.000126803,0.0008213373,0.002595253,0.0005892087,0.0000767103,0.00004695742],"genre_scores_gemma":[0.0008209953,0.9927868,0.00006470815,0.001391762,0.0005369816,0.001373854,0.002647268,0.0001986256,0.0001790225],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9299856,"threshold_uncertainty_score":0.9991532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619498803055073,"score_gpt":0.2846146519287078,"score_spread":0.268419663898157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}