{"id":"W4366201012","doi":"10.1101/2023.04.15.536946","title":"Molecular, metabolic and functional CD4 T cell paralysis impedes tumor control","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"CD8; Biology; T cell; Cancer research; Cd4 t cell; Cell biology; Effector; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001313537,0.0002790728,0.0001928471,0.0002005631,0.0001283432,0.000289802,0.0002142323,0.0002499853,0.00233404],"category_scores_gemma":[0.00009904566,0.0001148348,0.000126299,0.00009454246,0.0002420294,0.000158526,0.0002508883,0.0007510189,0.0005979885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003227926,"about_ca_system_score_gemma":0.0002917826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004676625,"about_ca_topic_score_gemma":0.0004272839,"domain_scores_codex":[0.9998596,0.00001608751,0.000008660652,0.00002257167,0.0000473938,0.00004558443],"domain_scores_gemma":[0.9999349,0.000009881452,0.00001397549,0.000010642,0.000008854069,0.0000218489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001536553,0.00002377681,0.0001612104,0.00002149412,0.000002455087,0.00003801521,0.000005985673,0.000142596,0.9973052,0.0004439483,0.00008830502,0.001613402],"study_design_scores_gemma":[0.00001366155,0.00008536628,0.001095052,0.000002645443,0.000004506132,0.0001221321,0.00001376463,0.001802418,0.9942133,0.0001593227,0.002485955,0.000001899507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872153,0.001126804,0.00549129,0.0002881047,0.00007412312,0.00003076356,0.0003165545,0.0001785857,0.00527846],"genre_scores_gemma":[0.989047,0.0002718653,0.002022011,0.00005798944,0.00001510132,0.00002074531,0.0002413038,0.000030442,0.008293619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00233404,"threshold_uncertainty_score":0.007808089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101175216390395,"score_gpt":0.2020572458959759,"score_spread":0.1910454937320719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}