{"id":"W4366205472","doi":"10.1002/cpz1.744","title":"Evaluation of Neurotoxicity With Human Pluripotent Stem Cell–Derived Cerebral Organoids","year":2023,"lang":"en","type":"article","venue":"Current Protocols","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Scottish Rite Charitable Foundation of Canada; Fondation Brain Canada","keywords":"Organoid; Neurogenesis; Induced pluripotent stem cell; Neuroscience; Human brain; Cell type; Biology; Cell; Embryonic stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001228072,0.000207985,0.0002054617,0.000115424,0.0001187084,0.00003466816,0.0003807774,0.00009797131,0.00006357683],"category_scores_gemma":[0.00003445704,0.0001764914,0.00008790613,0.0003537791,0.0001146788,0.000008779333,0.0002682384,0.0001661389,0.00005122106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004750625,"about_ca_system_score_gemma":0.0003219995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003919825,"about_ca_topic_score_gemma":0.000007466386,"domain_scores_codex":[0.997194,0.0004091905,0.0003289451,0.0005104169,0.001164559,0.0003929159],"domain_scores_gemma":[0.9984948,0.000009385707,0.0001812994,0.0005990627,0.0005936746,0.0001217669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000938177,0.0002296776,0.003599624,0.0003012026,0.00002980727,0.000001860465,0.00004725149,0.0003673693,0.9880471,0.00001067837,0.000889048,0.006382578],"study_design_scores_gemma":[0.002288716,0.0008415405,0.01171288,0.0001148496,0.00003452982,0.000002580891,0.00003732743,0.0008003486,0.9790375,0.00003792087,0.00487053,0.0002212591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.943815,0.00005330088,0.0002086469,0.00003264665,0.00005347884,0.05520528,0.00002861857,0.0000416261,0.0005613913],"genre_scores_gemma":[0.9392883,0.000007528484,0.00003152135,0.000007490471,0.0001113957,0.06002702,0.000146731,0.00003983428,0.0003401728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009009571,"threshold_uncertainty_score":0.7197112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08880275543392147,"score_gpt":0.3741156685560265,"score_spread":0.285312913122105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}