{"id":"W4366205472","doi":"10.1002/cpz1.744","title":"Evaluation of Neurotoxicity With Human Pluripotent Stem Cell–Derived Cerebral Organoids","year":2023,"lang":"en","type":"article","venue":"Current Protocols","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Scottish Rite Charitable Foundation of Canada; Fondation Brain Canada","keywords":"Organoid; Neurogenesis; Induced pluripotent stem cell; Neuroscience; Human brain; Cell type; Biology; Cell; Embryonic stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155158,0.000864303,0.0004101064,0.0006650485,0.0003393547,0.0004692982,0.0005038782,0.0005405131,0.002449486],"category_scores_gemma":[0.0003743486,0.0002636115,0.0005533851,0.0004137336,0.0004120973,0.0003722045,0.0003695877,0.001050302,0.0007399755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004088889,"about_ca_system_score_gemma":0.0004623565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009224473,"about_ca_topic_score_gemma":0.001544955,"domain_scores_codex":[0.9990613,0.000181837,0.0001811761,0.0001375028,0.0003667078,0.00007159428],"domain_scores_gemma":[0.9995512,0.0001442211,0.00006884406,0.0000717207,0.0001238879,0.00004004319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008828667,0.00006096218,0.0002626306,0.0002584231,0.00002305372,0.0001623447,0.00006917611,0.0005046985,0.9944533,0.000229558,0.0001797421,0.00370786],"study_design_scores_gemma":[0.0000125778,0.0004307945,0.001355178,0.00002135593,0.00004182902,0.00009232532,0.00003026617,0.0005788289,0.9933972,0.00006463596,0.003965996,0.000008964496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8502495,0.01893274,0.09813533,0.0004954169,0.0006908475,0.001896105,0.008734672,0.001238277,0.01962713],"genre_scores_gemma":[0.8764787,0.0211888,0.07417282,0.0004058129,0.00007725342,0.003467104,0.01248529,0.0001679386,0.01155628],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002449486,"threshold_uncertainty_score":0.008194327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08880275543392147,"score_gpt":0.3741156685560265,"score_spread":0.285312913122105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}