{"id":"W4366214532","doi":"10.1016/j.jid.2023.03.345","title":"340 Elevated tissue levels of granzyme k in psoriasis: A possible mechanism of cutaneous inflammation and epidermal hyperplasia","year":2023,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"","keywords":"Psoriasis; Inflammation; Hyperplasia; Medicine; Pathology; Granzyme A; Dermatology; Granzyme B; Immunology; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002827748,0.0001384548,0.0004252004,0.000247618,0.00002758542,0.000005873966,0.0001653442,0.0002199923,0.000007604189],"category_scores_gemma":[0.0006489334,0.0001241451,0.000057123,0.0002996146,0.0003334192,0.00001578657,0.00006476107,0.0001609558,0.000001705733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001190492,"about_ca_system_score_gemma":0.0002317157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009521346,"about_ca_topic_score_gemma":0.00001093377,"domain_scores_codex":[0.9985375,0.000220449,0.0007571608,0.0001479451,0.0001543847,0.0001825243],"domain_scores_gemma":[0.9987303,0.00007838296,0.000684347,0.0001179844,0.0003146261,0.000074368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008078839,0.00001787367,0.002329005,0.0001791425,0.00006942084,0.0001616648,0.0004990795,0.0001136025,0.9946221,0.001424433,0.0001191423,0.0003837255],"study_design_scores_gemma":[0.0007841733,0.0003112452,0.001693082,0.00009760263,0.00002964655,0.00283963,0.000389362,0.0002130149,0.9831619,0.01023605,0.0001409901,0.0001032706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983073,0.0005396803,0.00040627,0.0004313476,0.00009007368,0.0001017793,0.00001205351,0.000004309226,0.0001071526],"genre_scores_gemma":[0.9982958,0.0003322123,0.001213294,0.00004383678,0.00004903348,0.000003812225,0.0000118114,0.0000135334,0.00003670465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01146019,"threshold_uncertainty_score":0.5062488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01642193631795269,"score_gpt":0.2604285215050692,"score_spread":0.2440065851871165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}