{"id":"W4366215565","doi":"10.3390/molecules28083499","title":"Description of Chemical Synthesis, Nuclear Magnetic Resonance Characterization and Biological Activity of Estrane-Based Inhibitors/Activators of Steroidogenesis","year":2023,"lang":"en","type":"review","venue":"Molecules","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Steroid; Hormone; Aromatase; Chemistry; In vivo; Enzyme; Steroid sulfatase; Biochemistry; Steroid hormone; Pharmacology; Biology; Internal medicine; Cancer; Medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168809,0.0002542124,0.0008145514,0.00009627674,0.0000154771,0.000005103218,0.0001387262,0.0003975067,0.000006559753],"category_scores_gemma":[0.0001181111,0.0002172564,0.0002293846,0.0001697816,0.0002235658,0.000003815064,0.00009201071,0.00008103012,8.945077e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001132117,"about_ca_system_score_gemma":0.00008717024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001536418,"about_ca_topic_score_gemma":5.091262e-7,"domain_scores_codex":[0.9987533,0.0001611199,0.0004531558,0.0003621553,0.0001284464,0.0001418246],"domain_scores_gemma":[0.9991431,0.00004267454,0.0004308189,0.0002794329,0.00005819205,0.00004581125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000563642,0.00009233882,0.00004035801,0.003485833,0.00004769534,0.000001539813,0.000003941226,1.345045e-7,0.7229503,0.000007659158,0.000004987757,0.2733088],"study_design_scores_gemma":[0.0002096945,0.0003501902,0.0007929723,0.003313499,0.0003113046,0.00001114859,0.000005676766,0.000009607589,0.9657179,0.000003852531,0.02897588,0.0002983181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6252709,0.374153,0.000047128,0.000003953099,0.00002811711,0.0002250958,0.0002595948,0.000007524011,0.000004689483],"genre_scores_gemma":[0.2707775,0.7286842,0.0001494457,0.000002905235,0.00004899037,0.00002532066,0.0002630722,0.00004115078,0.000007395294],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.3545313,"threshold_uncertainty_score":0.885946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03741369177259505,"score_gpt":0.2599613010132007,"score_spread":0.2225476092406057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}