{"id":"W4366222007","doi":"10.3389/fimmu.2023.1179827","title":"LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa; McMaster University; Children's Hospital of Eastern Ontario; Discovery Centre","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001834472,0.0004473312,0.0002812647,0.0002394265,0.00009930773,0.0002981451,0.0002202104,0.0003351044,0.001520301],"category_scores_gemma":[0.0001084272,0.0001097897,0.0002287299,0.0001671004,0.0002235169,0.0002080419,0.0002037821,0.0008251321,0.0005987963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003244476,"about_ca_system_score_gemma":0.0002171453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002279235,"about_ca_topic_score_gemma":0.0003769486,"domain_scores_codex":[0.9998062,0.00002963318,0.00002367435,0.00003205846,0.00005259145,0.00005584466],"domain_scores_gemma":[0.9997336,0.00004371825,0.0001021069,0.0000280196,0.00001967849,0.00007280787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001703539,0.00006857533,0.000119244,0.00002298469,0.000002747173,0.00002742261,0.00001226324,0.00006824827,0.9987507,0.00004051242,0.00002538328,0.0006915497],"study_design_scores_gemma":[0.00002113399,0.0005713226,0.0008357659,0.000003713305,0.000008278013,0.0001114017,0.000007221953,0.0004594569,0.997059,0.0000138762,0.000907246,0.000001542826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970817,0.0007068132,0.0008056951,0.00007341115,0.00001454063,0.00003154931,0.0002254451,0.00007286391,0.0009880149],"genre_scores_gemma":[0.9955927,0.0003249401,0.001451471,0.00004215081,0.00001072507,0.00004466208,0.0004368398,0.00002579327,0.002070808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520301,"threshold_uncertainty_score":0.005085945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689990362478126,"score_gpt":0.2713708868426136,"score_spread":0.2544709832178323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}