{"id":"W4366225276","doi":"10.3389/fnagi.2023.1132077","title":"Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective","year":2023,"lang":"en","type":"review","venue":"Frontiers in Aging Neuroscience","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Western University; Lawson Health Research Institute","funders":"Fonds Wetenschappelijk Onderzoek","keywords":"Neuroscience; Blood–brain barrier; Biomarker; Medicine; Molecular imaging; Neuroimaging; Neuroinflammation; Disease; Bioinformatics; Pathology; Psychology; Central nervous system; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002173391,0.0004318188,0.001842711,0.0002597526,0.0002105992,0.0001284074,0.001463649,0.00007294474,0.00005933857],"category_scores_gemma":[0.001582023,0.0003057466,0.0006906726,0.001801635,0.0008152932,0.0003379545,0.0003752512,0.0006763419,0.00009251458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009537011,"about_ca_system_score_gemma":0.0004928457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000998566,"about_ca_topic_score_gemma":0.00001888669,"domain_scores_codex":[0.9947748,0.001308841,0.00138128,0.001291655,0.000727577,0.0005158319],"domain_scores_gemma":[0.9976461,0.0004809753,0.0007235247,0.0009084552,0.0001028427,0.0001380825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007351142,0.001004885,0.005126116,0.08904388,0.0002642746,0.001657294,0.001579734,0.0000717368,0.00397254,0.0008808799,0.2540981,0.6422271],"study_design_scores_gemma":[0.0003873261,0.00005492838,0.0002986528,0.06371606,0.0008480235,0.00006694171,0.0000666803,0.0001455388,0.0001324398,0.00276412,0.930778,0.0007412588],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000709848,0.9865682,0.002351547,0.0005125338,0.008984624,0.0009240892,0.0003256858,0.0001176779,0.0001446648],"genre_scores_gemma":[0.00002660065,0.9962307,0.001110831,0.001519623,0.0001313487,0.00007741691,0.00001077562,0.00005442664,0.0008383223],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.67668,"threshold_uncertainty_score":0.9999394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06422362725778254,"score_gpt":0.352871807854123,"score_spread":0.2886481805963405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}