{"id":"W4366235042","doi":"10.1039/d2cs01032a","title":"Carrier diversity and chemical ligations in the toolbox for designing tumor-associated carbohydrate antigens (TACAs) as synthetic vaccine candidates","year":2023,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Ministère de l'Économie, de la Science et de l'Innovation - Québec","keywords":"Toolbox; Computational biology; Diversity (politics); Chemistry; Carbohydrate; Antigen; Combinatorial chemistry; Biology; Biochemistry; Immunology; Computer science; Programming language","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005263554,0.0007630424,0.0006171204,0.00118698,0.0002889779,0.0009542602,0.0005094738,0.0007349118,0.00254095],"category_scores_gemma":[0.0003358659,0.0003940411,0.0003873109,0.001630691,0.0005865649,0.001350601,0.0006964019,0.001789394,0.002056655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006567038,"about_ca_system_score_gemma":0.0007369923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005154685,"about_ca_topic_score_gemma":0.0007502299,"domain_scores_codex":[0.9998285,0.00003321986,0.00001411977,0.00003075234,0.00006836813,0.00002511544],"domain_scores_gemma":[0.9999113,0.0000402241,0.00001420464,0.000006780228,0.00001813265,0.000009402504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008982167,0.0001225258,0.0001512875,0.01615582,0.00007135834,0.0005340071,0.0002456114,0.002181361,0.06483432,0.06796012,0.01642527,0.8312284],"study_design_scores_gemma":[0.000008704783,0.0001398504,0.0001875222,0.0009026286,0.00003430224,0.0007327402,0.00004983384,0.0002050036,0.01009946,0.003818409,0.9837984,0.00002320114],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002193245,0.9850919,0.004241832,0.0005501605,0.0005781412,0.00003543872,0.00005259657,0.00004879609,0.007207906],"genre_scores_gemma":[0.007427865,0.984821,0.003311467,0.0002774856,0.0002167041,0.00005095548,0.00007323776,0.00001116878,0.003810068],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00254095,"threshold_uncertainty_score":0.008500338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06636892117103857,"score_gpt":0.3454994344417552,"score_spread":0.2791305132707166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}