{"id":"W4366236771","doi":"10.2217/fon-2022-1196","title":"Design of SERENA-6, a phase III switching trial of camizestrant in <i>ESR1</i> -mutant breast cancer during first-line treatment","year":2023,"lang":"en","type":"article","venue":"Future Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"AstraZeneca","keywords":"Medicine; Mutant; Breast cancer; Oncology; Cancer; Line (geometry); Internal medicine; Cancer research; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002446686,0.001793274,0.00257803,0.0004484964,0.0005112399,0.00152763,0.0009277398,0.001533314,0.007970481],"category_scores_gemma":[0.001583478,0.0007021169,0.00124993,0.0003779494,0.001098124,0.001123439,0.000457088,0.003757961,0.001745276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008857214,"about_ca_system_score_gemma":0.002263509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006227182,"about_ca_topic_score_gemma":0.0018446,"domain_scores_codex":[0.9991552,0.0003337228,0.00005025447,0.0001840411,0.0000715116,0.0002053275],"domain_scores_gemma":[0.9991316,0.0001331881,0.0001322432,0.00007081424,0.00005644312,0.0004757429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9385995,0.02749463,0.0009024368,0.0004197065,0.0005917721,0.00007725199,0.00007016515,0.001316046,0.006379207,0.0004206679,0.001314819,0.02241381],"study_design_scores_gemma":[0.7526728,0.2397185,0.001720122,0.00003630237,0.000389321,0.00005393332,0.00003207103,0.0009453252,0.0009113112,0.000572752,0.002925639,0.00002186885],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9150139,0.003652948,0.003725565,0.001288972,0.001618599,0.05840068,0.003429234,0.000354581,0.01251549],"genre_scores_gemma":[0.9244323,0.002292856,0.005450339,0.002892994,0.0006606455,0.05138829,0.00222017,0.0000796276,0.01058265],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.007970481,"threshold_uncertainty_score":0.0266639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019315399695848,"score_gpt":0.354143198096221,"score_spread":0.3239500440992625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}