{"id":"W4366236771","doi":"10.2217/fon-2022-1196","title":"Design of SERENA-6, a phase III switching trial of camizestrant in <i>ESR1</i> -mutant breast cancer during first-line treatment","year":2023,"lang":"en","type":"article","venue":"Future Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"AstraZeneca","keywords":"Medicine; Mutant; Breast cancer; Oncology; Cancer; Line (geometry); Internal medicine; Cancer research; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002196447,0.0002560923,0.001065533,0.0002765761,0.00004739554,0.000002387458,0.0001058276,0.0001949615,0.0001399339],"category_scores_gemma":[0.00001555314,0.0001979508,0.0001281947,0.000552772,0.00007630509,0.00006785778,0.00003307494,0.0002108678,0.000003552724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000703231,"about_ca_system_score_gemma":0.0005938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001066119,"about_ca_topic_score_gemma":0.001317394,"domain_scores_codex":[0.9982646,0.0001074969,0.0006742477,0.0003373473,0.0002134104,0.0004029151],"domain_scores_gemma":[0.9989976,0.0001748686,0.0003368353,0.0002967924,0.0000882298,0.0001056175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4075116,0.002989146,0.0006983898,0.0003919741,0.0005624729,0.0008909811,0.007959361,0.006322346,0.3861565,0.00004201126,0.00002956683,0.1864457],"study_design_scores_gemma":[0.8866469,0.01343199,0.006895936,0.001028574,0.0006137905,0.000752871,0.002886276,0.001617002,0.0790986,0.0002145662,0.006299309,0.0005142461],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924985,0.0006492788,0.0006742883,0.003741739,0.0007445539,0.001430919,0.0001181146,0.0000761308,0.0000664811],"genre_scores_gemma":[0.9961213,0.001523325,0.0006920916,0.00007510644,0.001081946,0.0003098269,0.00002280217,0.00004334655,0.0001302806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4791353,"threshold_uncertainty_score":0.8072198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019315399695848,"score_gpt":0.354143198096221,"score_spread":0.3239500440992625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}