{"id":"W4366238718","doi":"10.1158/2159-8290.cd-22-0998","title":"Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Occupational Cancer Research Centre","funders":"Cancer Science Institute of Singapore, National University of Singapore; NIHR Cambridge Biomedical Research Centre; Medical Research Council; CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester; National University Cancer Institute, Singapore; Associazione Italiana per la Ricerca sul Cancro; National Research Foundation Singapore; Ministry of Education - Singapore; National Medical Research Council; National University of Singapore; National Research Foundation; National Institute for Health and Care Research; Fondazione Italiana per la Ricerca sul Cancro; Department of Health and Social Care; Cancer Research UK; Wellcome Trust","keywords":"Lymphoma; Oncogene; Biology; Cancer research; Single-cell analysis; Computational biology; Cell; Genetics; Immunology; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009664668,0.0001233167,0.000150652,0.00005495034,0.00003745346,0.00001322847,0.000147761,0.0001223401,0.000009114226],"category_scores_gemma":[0.00001861836,0.0001207797,0.00007121205,0.0001444649,0.00004124237,0.00001222513,0.0001104195,0.00003702246,0.000004847452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008546188,"about_ca_system_score_gemma":0.00008595013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000548604,"about_ca_topic_score_gemma":0.0009160689,"domain_scores_codex":[0.9990686,0.00004771762,0.0002230025,0.0002915915,0.0001419898,0.0002270533],"domain_scores_gemma":[0.9995854,0.00001540526,0.00008252751,0.0002381963,0.00003676242,0.000041691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002056974,0.00007972611,0.1586708,0.00006308907,0.000007920083,0.000004006431,0.00006275201,0.002671062,0.8372146,0.000003711174,0.0002057346,0.0008108416],"study_design_scores_gemma":[0.0009866555,0.0001165602,0.08597302,0.000115753,0.000008775195,8.072035e-7,0.00005485651,0.0001276141,0.9097573,0.00001057555,0.002686615,0.0001615306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980678,0.0007139715,0.0002648692,0.00003300177,0.0003750832,0.0001034118,0.0001529413,0.00001233735,0.0002765619],"genre_scores_gemma":[0.9973379,0.001015442,0.00001570392,0.00006826006,0.0001151705,0.00002227437,0.0001813989,0.00002168657,0.001222109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07269782,"threshold_uncertainty_score":0.4925254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085011946229744,"score_gpt":0.2521809049532242,"score_spread":0.2313307854909268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}