{"id":"W4366238718","doi":"10.1158/2159-8290.cd-22-0998","title":"Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Occupational Cancer Research Centre","funders":"Cancer Science Institute of Singapore, National University of Singapore; NIHR Cambridge Biomedical Research Centre; Medical Research Council; CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester; National University Cancer Institute, Singapore; Associazione Italiana per la Ricerca sul Cancro; National Research Foundation Singapore; Ministry of Education - Singapore; National Medical Research Council; National University of Singapore; National Research Foundation; National Institute for Health and Care Research; Fondazione Italiana per la Ricerca sul Cancro; Department of Health and Social Care; Cancer Research UK; Wellcome Trust","keywords":"Lymphoma; Oncogene; Biology; Cancer research; Single-cell analysis; Computational biology; Cell; Genetics; Immunology; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000487256,0.0001255291,0.0002600448,0.0004249689,0.0001547979,0.0006588673,0.0001438618,0.0002110106,0.0004445439],"category_scores_gemma":[0.001461962,0.0001530181,0.0001786732,0.0005247496,0.0002258315,0.000323464,0.0003587389,0.0002778934,0.0001565414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003710135,"about_ca_system_score_gemma":0.0001267659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006628879,"about_ca_topic_score_gemma":0.001308108,"domain_scores_codex":[0.9997064,0.00006076978,0.00001768812,0.0001020893,0.00007544178,0.00003760507],"domain_scores_gemma":[0.9992839,0.0002816246,0.0002469659,0.00007174215,0.00007631525,0.00003951748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004276557,0.00003453586,0.2217923,0.0001077349,0.00009892703,0.00006234599,0.0001974037,0.007254498,0.7456319,0.0003830875,0.0002311324,0.02377842],"study_design_scores_gemma":[0.000009447435,0.0001937692,0.7729464,0.00001859603,0.0001181565,0.000418855,0.0003460363,0.04679226,0.1759591,0.001345864,0.001811782,0.00003982442],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920813,0.0004254537,0.00653764,0.00003514998,0.000002684677,0.000007006884,0.0004768276,0.00006149189,0.0003724214],"genre_scores_gemma":[0.9977329,0.0001303349,0.001550079,0.0000190881,0.000003154654,0.00001194275,0.0003972359,0.00001440132,0.0001408629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006628879,"threshold_uncertainty_score":0.002691865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085011946229744,"score_gpt":0.2521809049532242,"score_spread":0.2313307854909268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}