{"id":"W4366292016","doi":"10.21203/rs.3.rs-2794960/v1","title":"Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University; University of Alberta; University of Calgary; Royal Alexandra Hospital; Thrombosis and Atherosclerosis Research Institute; University of Ottawa; McMaster University; University of Manitoba; Ottawa Hospital","funders":"Ottawa Hospital Anesthesia Alternate Funds Association; Manitoba Medical Service Foundation; McMaster University; Canadian Institutes of Health Research; Royal Alexandra Hospital Foundation; University of Ottawa","keywords":"Peritonitis; Feces; Sepsis; Medicine; Internal medicine; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008221408,0.0002570004,0.0007215953,0.000760502,0.0001340248,0.00003731324,0.0001509951,0.000250005,0.00002135602],"category_scores_gemma":[0.0004004409,0.0002535372,0.00006747126,0.0004789424,0.0002791947,0.00007727936,0.0007463146,0.0006711847,0.000002735343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184937,"about_ca_system_score_gemma":0.001014813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006907786,"about_ca_topic_score_gemma":0.00005777425,"domain_scores_codex":[0.9964782,0.0003516151,0.0009497834,0.0007245661,0.001193956,0.0003019085],"domain_scores_gemma":[0.997041,0.0002550573,0.000310578,0.0005842035,0.001605568,0.0002035482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009806693,0.002195554,0.001809367,0.0009927936,0.0002849185,0.00001687439,0.02320851,0.00002690036,0.9699392,0.00001386807,0.00001219373,0.0005191687],"study_design_scores_gemma":[0.00363019,0.0007934017,0.06630663,0.001648302,0.00005700081,9.326894e-7,0.01407447,0.02677331,0.8865286,0.000007084321,0.000004789551,0.000175354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907243,0.0002164037,0.00003819197,0.0001438953,0.00003191158,0.002694797,0.006098215,0.00002471574,0.00002762597],"genre_scores_gemma":[0.9955504,0.0003317649,0.0007567861,0.000002079308,0.00004658668,0.0005243643,0.002610482,0.00004582907,0.0001317068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08341064,"threshold_uncertainty_score":0.9999917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2130681778298358,"score_gpt":0.4388629293660206,"score_spread":0.2257947515361848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}