{"id":"W4366334847","doi":"10.21203/rs.3.rs-2807590/v1","title":"A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; National Key Research and Development Program of China; State Key Laboratory of Environmental Chemistry and Ecotoxicology; Natural Science Foundation of Tianjin City; Chinese Academy of Sciences; Institute of Genetics; National Natural Science Foundation of China","keywords":"Fungal keratitis; Candida albicans; Inflammasome; TLR4; Biology; Innate immune system; Pyroptosis; Microbiology; S100A8; S100A9; Proinflammatory cytokine; Immunology; Immune system; Keratitis; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699262,0.0005227054,0.0003056105,0.0004067247,0.0002631254,0.0004754499,0.0002104636,0.0004185464,0.001426615],"category_scores_gemma":[0.000137319,0.0001983084,0.0004665565,0.0001868351,0.0003519352,0.000409804,0.0004551495,0.0006243792,0.0003772398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003874216,"about_ca_system_score_gemma":0.0002964999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003774797,"about_ca_topic_score_gemma":0.0003655627,"domain_scores_codex":[0.9997799,0.00003287291,0.00002543686,0.00005255121,0.00005535141,0.00005406095],"domain_scores_gemma":[0.9998606,0.000007705465,0.00004311964,0.000009638034,0.00002935099,0.00004952784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002252229,0.00002458429,0.0008833197,0.0001001455,0.00001195586,0.0001941324,0.00001608631,0.0000539403,0.9967974,0.0001057114,0.00010887,0.001478659],"study_design_scores_gemma":[0.00008629842,0.0006428062,0.05738107,0.0000663896,0.00007541705,0.001131501,0.0003016978,0.005339502,0.927766,0.0009526306,0.006225563,0.00003108578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857962,0.004280968,0.006324124,0.0004418465,0.0001205508,0.00006292054,0.0007079158,0.0002846218,0.001980884],"genre_scores_gemma":[0.9943166,0.0009140504,0.002837369,0.000125433,0.00002271138,0.00004137072,0.0003136175,0.00001333995,0.001415454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001426615,"threshold_uncertainty_score":0.004772484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458891407370579,"score_gpt":0.3261149986127779,"score_spread":0.3015260845390721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}