{"id":"W4366336896","doi":"10.1101/2023.04.17.537197","title":"Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver Injury","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Acetaminophen; Liver injury; Medicine; Messenger RNA; Toxicity; Testosterone (patch); Hormone; Programmed cell death; Pharmacology; Endocrinology; Internal medicine; Biology; Apoptosis; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171601,0.0005055317,0.0002470766,0.0003577116,0.0001350845,0.0001808188,0.0001813545,0.0002824829,0.001825899],"category_scores_gemma":[0.00008778473,0.00009233823,0.0003195614,0.0001449172,0.0002699961,0.0001556602,0.0001822458,0.0008342516,0.0004068953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002126399,"about_ca_system_score_gemma":0.0003146482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004489462,"about_ca_topic_score_gemma":0.0009089586,"domain_scores_codex":[0.9998413,0.00001954448,0.00001341781,0.00003190483,0.0000609312,0.0000328291],"domain_scores_gemma":[0.9998652,0.00001491337,0.00004791744,0.00001853908,0.00001568621,0.00003765971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003816033,0.0001254674,0.0001657302,0.0000591777,0.000005810905,0.00004930435,0.00002349855,0.0001058957,0.9958312,0.0000580388,0.00008243629,0.003111801],"study_design_scores_gemma":[0.00002757554,0.001849626,0.001733651,0.000006171058,0.00001197235,0.0001082729,0.00002695307,0.0004564553,0.9942749,0.0000225743,0.001477592,0.00000426453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889276,0.001842952,0.004286158,0.00029654,0.0001454281,0.0001013353,0.0008980557,0.0002828326,0.003219091],"genre_scores_gemma":[0.9825107,0.001644275,0.004698845,0.0001624422,0.00003847126,0.0001567501,0.0009123002,0.00007866361,0.009797415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825899,"threshold_uncertainty_score":0.006108224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1090288470938373,"score_gpt":0.3336889906025077,"score_spread":0.2246601435086705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}