{"id":"W4366339432","doi":"10.1101/2023.04.17.537186","title":"VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Liver physiology and pathology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Steatosis; Hepatocyte; Fibrosis; Medicine; Liver fibrosis; Internal medicine; Gastroenterology; Chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276491,0.0002613682,0.0002208743,0.0001825707,0.0001130306,0.000157081,0.00008842038,0.0002348573,0.001537328],"category_scores_gemma":[0.00009228138,0.00009164043,0.0002190183,0.00007978371,0.0002500797,0.0002018892,0.0001302208,0.0005824149,0.0002430462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002235048,"about_ca_system_score_gemma":0.0003072974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000685771,"about_ca_topic_score_gemma":0.0009748692,"domain_scores_codex":[0.9999096,0.000012199,0.000009757759,0.00002246635,0.00002519956,0.00002076337],"domain_scores_gemma":[0.9999487,0.000004337158,0.00001613298,0.000004842382,0.000008126364,0.00001786077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002606634,0.00006068751,0.0001417136,0.00009355698,0.000006548534,0.00004487504,0.00001237595,0.00005964064,0.9945385,0.0001909108,0.0001108439,0.00447965],"study_design_scores_gemma":[0.00005772442,0.001210036,0.002394786,0.00001014239,0.00003503401,0.0002580706,0.00002277459,0.0006359507,0.9912573,0.00009061014,0.004021826,0.000005890311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838087,0.004428874,0.00758115,0.0003064673,0.0001512935,0.00008906874,0.000369286,0.0004241285,0.002840984],"genre_scores_gemma":[0.990405,0.001772216,0.002595638,0.0001017125,0.00002155219,0.00007900051,0.0003057267,0.00003822212,0.00468095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537328,"threshold_uncertainty_score":0.005142868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463134516425653,"score_gpt":0.2258123015575075,"score_spread":0.211180956393251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}