{"id":"W4366350974","doi":"10.1152/jn.00111.2023","title":"Optogenetic activation of septal inhibitory cells abates focal seizures","year":2023,"lang":"en","type":"article","venue":"Journal of Neurophysiology","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Savoy Foundation; Government of Canada","keywords":"Optogenetics; Pilocarpine; Parvalbumin; Stimulation; Inhibitory postsynaptic potential; Epilepsy; Neuroscience; Status epilepticus; Deep brain stimulation; Medicine; Temporal lobe; Anesthesia; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007937105,0.0001154075,0.0002615806,0.0003455202,0.00006290359,0.00001333469,0.000370396,0.0000743414,0.00006362619],"category_scores_gemma":[0.0003942481,0.00009493887,0.0001996317,0.0004859431,0.0002261834,0.00009060176,0.0001347683,0.0003054263,0.00006304016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001889548,"about_ca_system_score_gemma":0.00009789639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002563003,"about_ca_topic_score_gemma":9.666791e-8,"domain_scores_codex":[0.9984369,0.0002859647,0.0004134117,0.0001929227,0.0003943383,0.000276514],"domain_scores_gemma":[0.9988229,0.00051185,0.000271594,0.0001576337,0.0001337626,0.0001022913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001745974,0.00006989062,0.00002558927,0.00002325002,0.000008522598,0.00006736511,0.0000995707,0.00407652,0.9940836,0.00002271483,0.0005059837,0.0008423571],"study_design_scores_gemma":[0.0003288912,0.001013936,0.008348813,0.00001637605,0.000006964457,0.00004714094,0.00002424921,0.0009848549,0.9879972,0.0003212605,0.0008353488,0.00007492361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989025,0.00001194867,0.0000194019,0.00008387381,0.0007164284,0.0000833314,0.000008412018,0.0000146779,0.0001594477],"genre_scores_gemma":[0.9990697,0.0003318443,0.00005131609,0.000136389,0.0002795796,0.000001856008,8.0725e-7,0.00002076611,0.0001077658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008323223,"threshold_uncertainty_score":0.3871495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04904273958445114,"score_gpt":0.320311571544489,"score_spread":0.2712688319600379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}