{"id":"W4366350987","doi":"10.1111/epi.17621","title":"Time‐to‐event clinical trial designs: Existing evidence and remaining concerns","year":2023,"lang":"en","type":"review","venue":"Epilepsia","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; H. Lundbeck A/S; Sunovion; Epilepsy Society; Eisai; Health Canada; Radius Health; Pfizer; Angelini Pharma; SK Life Science; American Epilepsy Society","keywords":"Clinical trial; Placebo; Randomization; Clinical study design; Medicine; Epilepsy; Research design; Randomized controlled trial; Physical therapy; Alternative medicine; Psychiatry; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2870862,0.001997833,0.009388571,0.002718591,0.0009007594,0.006558562,0.005500386,0.006889374,0.01036824],"category_scores_gemma":[0.4473368,0.001441259,0.009116178,0.005027183,0.004910079,0.007945011,0.00241904,0.008041106,0.001851605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004611264,"about_ca_system_score_gemma":0.008247662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001719023,"about_ca_topic_score_gemma":0.003160547,"domain_scores_codex":[0.7368079,0.1991867,0.03682403,0.006204662,0.02007503,0.0009015843],"domain_scores_gemma":[0.3276642,0.6219322,0.02387694,0.0123144,0.01311956,0.001092783],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007094342,0.0001909453,0.0012341,0.3589497,0.01531622,0.0001639019,0.0006358433,0.001015484,0.0003801228,0.02912297,0.01687321,0.5690232],"study_design_scores_gemma":[0.00954876,0.003841726,0.003539408,0.5219215,0.03606745,0.0009670968,0.0006894154,0.00225869,0.001198665,0.08115814,0.3385479,0.0002612812],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005117381,0.9722236,0.01038921,0.009721966,0.003186161,0.001696053,0.0002483427,0.00007437942,0.001948416],"genre_scores_gemma":[0.03121781,0.8739764,0.05341625,0.0241152,0.005089423,0.009965382,0.0004979408,0.000212582,0.001508999],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7129139,"threshold_uncertainty_score":0.8791497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6551589409700829,"score_gpt":0.578101633566941,"score_spread":0.07705730740314187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}