{"id":"W4366351020","doi":"10.1007/s11523-023-00957-7","title":"Place in Therapy of Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer: A Targeted Literature Review","year":2023,"lang":"en","type":"review","venue":"Targeted Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"EVERSANA (Canada)","funders":"Pfizer","keywords":"Medicine; Oncology; Metastatic breast cancer; Breast cancer; Internal medicine; Palbociclib; Targeted therapy; Chemotherapy; Cyclin-dependent kinase 4; Cancer; Clinical trial; Cell cycle; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001006491,0.0009881755,0.006519103,0.001370503,0.00003254988,0.000009233269,0.0004903257,0.001250966,0.0004330504],"category_scores_gemma":[0.0001875708,0.0007876815,0.0006964157,0.003689762,0.0002145214,0.0001286385,0.0001581488,0.002314442,0.00005961083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002348232,"about_ca_system_score_gemma":0.002833559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00038843,"about_ca_topic_score_gemma":0.0005301843,"domain_scores_codex":[0.9940795,0.0009501642,0.002441122,0.001097409,0.0005239445,0.0009078669],"domain_scores_gemma":[0.9967598,0.0005124359,0.001348197,0.0008600546,0.0002740484,0.0002454765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006893022,0.000534559,0.0001656713,0.06671678,0.0003871562,0.001690596,0.0003693348,0.00001049555,0.00007091243,0.00001712544,0.001089234,0.9282588],"study_design_scores_gemma":[0.003495185,0.0003348967,0.0002325275,0.2431091,0.0003089466,0.0006242805,0.00004319963,0.000003160072,0.00001620328,0.00006594577,0.7512399,0.0005266579],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001120028,0.9918593,0.000001563288,0.001838486,0.0008648305,0.004259733,0.0007966116,0.0001506002,0.0001168592],"genre_scores_gemma":[0.00004174427,0.9950386,0.0002384123,0.0009730776,0.0005224151,0.001858156,0.0006970182,0.0002459978,0.0003846113],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9277322,"threshold_uncertainty_score":0.9999872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03738858245496208,"score_gpt":0.3918227242008502,"score_spread":0.3544341417458882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}