{"id":"W4366351020","doi":"10.1007/s11523-023-00957-7","title":"Place in Therapy of Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer: A Targeted Literature Review","year":2023,"lang":"en","type":"review","venue":"Targeted Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"EVERSANA (Canada)","funders":"Pfizer","keywords":"Medicine; Oncology; Metastatic breast cancer; Breast cancer; Internal medicine; Palbociclib; Targeted therapy; Chemotherapy; Cyclin-dependent kinase 4; Cancer; Clinical trial; Cell cycle; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003084362,0.001047294,0.003552692,0.01042801,0.0004847493,0.002056062,0.001396242,0.001806616,0.004231306],"category_scores_gemma":[0.01014508,0.0006262527,0.002901756,0.01221354,0.0005386778,0.002434754,0.001065444,0.001159102,0.0006451657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002393554,"about_ca_system_score_gemma":0.007270555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004639842,"about_ca_topic_score_gemma":0.009005884,"domain_scores_codex":[0.9977717,0.0005762371,0.0009143932,0.0001904968,0.0004435422,0.0001035863],"domain_scores_gemma":[0.9906868,0.006184435,0.001548077,0.0001159806,0.001317624,0.0001470858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002010765,0.0000535181,0.0005355667,0.7125571,0.001271137,0.0003231352,0.0003574182,0.0002380739,0.0005708071,0.001317982,0.01312137,0.2694528],"study_design_scores_gemma":[0.00009078503,0.0002178104,0.002774384,0.7955472,0.01133947,0.001308377,0.0004353059,0.0001147453,0.0002869258,0.0009587787,0.1868907,0.0000354242],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001795237,0.998922,0.000053361,0.0003213694,0.0001519425,0.00002575165,0.00005674715,0.000003024634,0.0002863929],"genre_scores_gemma":[0.001311477,0.9978169,0.0001624622,0.0004254459,0.0001100802,0.00003630724,0.00005285525,0.000001567609,0.00008285455],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01042801,"threshold_uncertainty_score":0.01736659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03738858245496208,"score_gpt":0.3918227242008502,"score_spread":0.3544341417458882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}