{"id":"W4366351779","doi":"10.1128/spectrum.04646-22","title":"Collateral Changes in Cell Physiology Associated with ADC-7 β-Lactamase Expression in Acinetobacter baumannii","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Guelph","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Office of Research and Development; Geriatric Research Education and Clinical Center; NIH Clinical Center; National Institutes of Health; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Acinetobacter baumannii; Peptidoglycan; Carbonic anhydrase; Viability assay; Mutant; Microbiology; Biology; Transposable element; Enzyme; Biochemistry; Gene; Chemistry; Cell; Bacteria; Genetics; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962985,0.0002642032,0.0003466986,0.0001959789,0.00004513163,0.00001265774,0.0002435003,0.0004115411,0.00009077517],"category_scores_gemma":[0.00002786328,0.000223303,0.00004356419,0.0003403077,0.0001732635,0.00000528346,0.000168545,0.0001992194,0.00005551308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000631006,"about_ca_system_score_gemma":0.00005387658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000266098,"about_ca_topic_score_gemma":0.003633407,"domain_scores_codex":[0.9982134,0.0002101865,0.0002550058,0.0006146108,0.00003523294,0.0006716276],"domain_scores_gemma":[0.9994337,0.00003218528,0.0001267248,0.0003405686,0.00002047493,0.00004637484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003677737,0.00008493465,0.07836219,0.00001350263,0.00001605954,0.00004933093,0.00006618195,0.00003117587,0.9186352,0.000001886563,0.002351942,0.00001975233],"study_design_scores_gemma":[0.001489753,0.0003707772,0.3437018,0.00006671677,0.000004930571,0.00001222084,0.00007599885,0.00001057353,0.6500083,0.00002554937,0.003961196,0.0002720887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985142,0.00009318033,0.000004585872,0.0005015863,0.0001892995,0.0002740294,0.00006907531,0.00003613283,0.0003179057],"genre_scores_gemma":[0.9968106,0.0001192571,0.00006720542,0.0002600481,0.00009780729,0.00002003739,0.001237172,0.00003729032,0.001350544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2686269,"threshold_uncertainty_score":0.9106031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0060856568674917,"score_gpt":0.2126305927915164,"score_spread":0.2065449359240247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}