{"id":"W4366351779","doi":"10.1128/spectrum.04646-22","title":"Collateral Changes in Cell Physiology Associated with ADC-7 β-Lactamase Expression in Acinetobacter baumannii","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Guelph","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Office of Research and Development; Geriatric Research Education and Clinical Center; NIH Clinical Center; National Institutes of Health; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Acinetobacter baumannii; Peptidoglycan; Carbonic anhydrase; Viability assay; Mutant; Microbiology; Biology; Transposable element; Enzyme; Biochemistry; Gene; Chemistry; Cell; Bacteria; Genetics; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007324541,0.0001144323,0.0001894963,0.00015199,0.0001720596,0.0003360022,0.00008479365,0.0002325325,0.001121739],"category_scores_gemma":[0.0001674297,0.0000816076,0.0001171279,0.0001880434,0.0001973761,0.0002000466,0.0001898671,0.0004228076,0.0002503433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002435073,"about_ca_system_score_gemma":0.0001353551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044832,"about_ca_topic_score_gemma":0.0008550911,"domain_scores_codex":[0.9998701,0.00001576889,0.00001183985,0.00002623357,0.00003675167,0.00003945339],"domain_scores_gemma":[0.9999019,0.00001486502,0.00001888881,0.0000147296,0.00002095372,0.00002872963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001070779,0.00001223183,0.001140737,0.00001063824,0.000001723198,0.0000961842,0.00003409797,0.00002076166,0.9977817,0.00004517617,0.00004369689,0.0007060575],"study_design_scores_gemma":[0.00001960614,0.0006136544,0.2502416,0.0000133268,0.0000180137,0.001598336,0.0008465386,0.001711621,0.7411194,0.0004107417,0.003384006,0.00002310201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972837,0.0005446881,0.0005650812,0.0001662222,0.00002041528,0.000007875221,0.0004860404,0.00003684727,0.0008891421],"genre_scores_gemma":[0.9982733,0.00023597,0.0003140985,0.00004992425,0.000006312873,0.00001341489,0.0002899598,0.000004872783,0.0008122457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121739,"threshold_uncertainty_score":0.00375253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0060856568674917,"score_gpt":0.2126305927915164,"score_spread":0.2065449359240247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}