{"id":"W4366352907","doi":"10.1038/s41434-023-00400-6","title":"rAAV-PHP.B escapes the mouse eye and causes lethality whereas rAAV9 can transduce aniridic corneal limbal stem cells without lethality","year":2023,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Corneal Surgery and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Knowledge Development Fund; Foundation Fighting Blindness; Government of Canada; Canada Foundation for Innovation; BC Children's Hospital","keywords":"Aniridia; PAX6; Gene delivery; Biology; Genetic enhancement; Transduction (biophysics); Adeno-associated virus; Virology; Ophthalmology; Medicine; Genetics; Gene; Recombinant DNA; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00074999,0.0003719207,0.0005751495,0.00007030833,0.0002981442,0.00005890588,0.0001538548,0.0001413788,0.0001258515],"category_scores_gemma":[0.00000975089,0.000244674,0.0001891426,0.0003645266,0.0002277227,0.00007534733,0.00003929676,0.0002624934,0.00005962257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008648998,"about_ca_system_score_gemma":0.0001702753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001276346,"about_ca_topic_score_gemma":0.0004556771,"domain_scores_codex":[0.9977145,0.0003989031,0.0003824711,0.000553307,0.0004098239,0.0005410296],"domain_scores_gemma":[0.998655,0.000237115,0.0001174806,0.0006438345,0.00007686829,0.0002696899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004220915,0.001076798,0.4835261,0.0001726004,0.001584209,0.0005852827,0.006984985,0.00004070981,0.4015684,0.00006086641,0.003595714,0.09658346],"study_design_scores_gemma":[0.006171733,0.0008765261,0.3964983,0.0000658014,0.000282768,0.0001279992,0.0006909568,0.00009131361,0.5724793,0.0001775095,0.02196316,0.0005746634],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99233,0.002459035,0.00001551408,0.003501733,0.0002508008,0.0008290656,0.0001588359,0.0002833567,0.0001716709],"genre_scores_gemma":[0.9898445,0.00453776,0.00002537533,0.001310561,0.0002111692,0.00007140655,0.00006838947,0.00005849573,0.003872324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1709109,"threshold_uncertainty_score":0.9977517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04837754732226573,"score_gpt":0.2921559127128007,"score_spread":0.243778365390535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}