{"id":"W4366353534","doi":"10.1097/hep.0000000000000413","title":"Use of HBV RNA and to predict change in serological status and disease activity in CHB","year":2023,"lang":"en","type":"article","venue":"Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; NIH Clinical Center; Baylor University Medical Center; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; University of Pennsylvania; Novo Nordisk; Abbott Diagnostics; Gilead Sciences; Georgia Clinical and Translational Science Alliance; Virginia Commonwealth University; National Institute of Diabetes and Digestive and Kidney Diseases; Baylor University; Mallinckrodt Pharmaceuticals; David Geffen School of Medicine, University of California, Los Angeles; University of Minnesota; National Institute on Alcohol Abuse and Alcoholism; University of Toronto; Saint Louis University; GlaxoSmithKline; Pfizer; University of Washington; Bristol-Myers Squibb","keywords":"HBsAg; Medicine; HBeAg; Hepatitis B virus; Hepatitis B; Serology; Internal medicine; Immunology; Population; Virology; Virus; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193461,0.00009055364,0.0003746304,0.0002264394,0.00001565989,0.000002655332,0.00002007414,0.00007737485,0.00001292623],"category_scores_gemma":[0.0008778148,0.00007853469,0.00001379141,0.0002672633,0.0001230808,0.0000608186,0.0001585006,0.0001198074,0.000006867983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003164379,"about_ca_system_score_gemma":0.00003901904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005310681,"about_ca_topic_score_gemma":0.01643518,"domain_scores_codex":[0.9991407,0.0001000172,0.000148548,0.0002327914,0.0000804437,0.0002974872],"domain_scores_gemma":[0.9994243,0.00019836,0.00002611481,0.0001197673,0.00002089076,0.000210604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00050496,0.00007298418,0.9938554,0.0000967145,0.00001027182,0.0004506579,0.000786858,4.206759e-7,0.0003021471,0.00009936719,0.0002011096,0.003619135],"study_design_scores_gemma":[0.0006470075,0.0002835049,0.9964634,0.00004511623,0.00001383041,0.000005597276,0.00001295286,0.001635236,0.00005012376,0.0001192197,0.0006675735,0.00005639462],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955971,0.0002531424,0.000002123433,0.003582436,0.00004686919,0.0004097531,0.00004654657,0.00003279939,0.00002926637],"genre_scores_gemma":[0.9973864,0.001692477,0.00004586968,0.000721739,0.00001808182,0.0001006093,0.000005647675,0.000007882652,0.00002128296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0111245,"threshold_uncertainty_score":0.9171218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1206188397204463,"score_gpt":0.3416816834931153,"score_spread":0.221062843772669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}