{"id":"W4366365187","doi":"10.1093/neuonc/noad078","title":"LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster Children's Hospital","funders":"Norgine; Deutschen Konsortium für Translationale Krebsforschung; Universität Heidelberg; Servier; Medizinische Universität Wien; National and Kapodistrian University of Athens; PharmaMar; Alexion Pharmaceuticals; University of New South Wales; Jazz Pharmaceuticals; Deutsche Kinderkrebsstiftung; McMaster University; Deutsches Krebsforschungszentrum; Univerzita Karlova v Praze; Universitätsklinikum Heidelberg; Freie Universität Berlin; Brain Tumour Charity; Sanofi; Universität Wien; Semmelweis Egyetem; Pfizer; Rigshospitalet; Amgen; Humboldt-Universität zu Berlin; Eli Lilly and Company; Pediatric Brain Tumor Foundation","keywords":"RNA; Medicine; Fusion gene; DNA methylation; RNA-Seq; Gene; Oncology; Bioinformatics; Internal medicine; Cancer research; Biology; Genetics; Transcriptome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0006466522,0.0002288291,0.0007534098,0.0003996329,0.00003363298,0.00001155949,0.0006277749,0.000384979,0.00004804889],"category_scores_gemma":[0.01081235,0.0001890886,0.0002042423,0.0005445328,0.000170096,0.0001010217,0.000402604,0.0003546459,0.00003815851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048121,"about_ca_system_score_gemma":0.0003633916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002728984,"about_ca_topic_score_gemma":0.00003303399,"domain_scores_codex":[0.9969048,0.0002765531,0.001180188,0.0008636506,0.000378015,0.0003968165],"domain_scores_gemma":[0.9929224,0.005161854,0.0004215614,0.001034209,0.0001900894,0.0002698422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006146518,0.008619723,0.9618371,0.00008424441,0.0001063231,0.002179057,0.00003912909,0.00004316034,0.003837041,0.0001980119,0.01046954,0.01197207],"study_design_scores_gemma":[0.02386089,0.009979989,0.9488806,0.00008090838,0.0006461224,0.00005933146,0.00004777523,0.005094383,0.002979133,0.0004255019,0.007660383,0.0002850428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936886,0.00006504865,0.00001423916,0.00255148,0.001854939,0.001098405,0.0005852107,0.00006411292,0.00007799914],"genre_scores_gemma":[0.9945018,0.0004692309,0.0005794699,0.0008822586,0.0005388112,0.0001775919,0.002800482,0.00004660384,0.00000376821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02324624,"threshold_uncertainty_score":0.99752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1093993735418929,"score_gpt":0.4281708339732458,"score_spread":0.3187714604313528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}