{"id":"W4366365187","doi":"10.1093/neuonc/noad078","title":"LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster Children's Hospital","funders":"Norgine; Deutschen Konsortium für Translationale Krebsforschung; Universität Heidelberg; Servier; Medizinische Universität Wien; National and Kapodistrian University of Athens; PharmaMar; Alexion Pharmaceuticals; University of New South Wales; Jazz Pharmaceuticals; Deutsche Kinderkrebsstiftung; McMaster University; Deutsches Krebsforschungszentrum; Univerzita Karlova v Praze; Universitätsklinikum Heidelberg; Freie Universität Berlin; Brain Tumour Charity; Sanofi; Universität Wien; Semmelweis Egyetem; Pfizer; Rigshospitalet; Amgen; Humboldt-Universität zu Berlin; Eli Lilly and Company; Pediatric Brain Tumor Foundation","keywords":"RNA; Medicine; Fusion gene; DNA methylation; RNA-Seq; Gene; Oncology; Bioinformatics; Internal medicine; Cancer research; Biology; Genetics; Transcriptome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007174732,0.0003569388,0.0006596373,0.002984863,0.0003829832,0.001891394,0.001226567,0.0006193358,0.006245268],"category_scores_gemma":[0.01795054,0.0002573868,0.0003144113,0.00401125,0.0002417663,0.000876456,0.001463404,0.0005317653,0.002747171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00152096,"about_ca_system_score_gemma":0.00315378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007283655,"about_ca_topic_score_gemma":0.01098596,"domain_scores_codex":[0.996243,0.001343692,0.000574261,0.0009864962,0.0005675189,0.0002850982],"domain_scores_gemma":[0.9759137,0.005208199,0.00719424,0.003367329,0.006054589,0.002261938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002841089,0.000193407,0.8291119,0.0005331726,0.0002266904,0.0003570275,0.0004229666,0.001346539,0.003482066,0.0009647284,0.09322435,0.06729607],"study_design_scores_gemma":[0.0007024744,0.0004263226,0.8943226,0.0005020365,0.0003401567,0.001024145,0.0006488946,0.005648156,0.005105147,0.0007811873,0.0904033,0.00009562123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.4747168,0.002666642,0.01052424,0.005922493,0.0003156985,0.0009271731,0.4846268,0.001836274,0.01846388],"genre_scores_gemma":[0.5368072,0.001044441,0.02487326,0.002294795,0.0004118428,0.002114922,0.429673,0.0005251134,0.00225539],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007283655,"threshold_uncertainty_score":0.03794408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1093993735418929,"score_gpt":0.4281708339732458,"score_spread":0.3187714604313528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}