{"id":"W4366371511","doi":"10.1080/19336950.2023.2191773","title":"A governance of ion selectivity based on the occupancy of the “beacon” in one- and four-domain calcium and sodium channels","year":2023,"lang":"en","type":"article","venue":"Channels","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Compute Canada","keywords":"Selectivity; Calcium; Occupancy; Chemistry; Sodium channel; Sodium; Ion channel; Biophysics; Molecular beacon; Domain (mathematical analysis); Computer science; Biochemistry; Gene; Biology; Receptor; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003823608,0.0001392797,0.0002698463,0.0002567953,0.0003076266,0.0006275429,0.0004176095,0.0003938019,0.000661707],"category_scores_gemma":[0.0006239262,0.0001648313,0.0002462728,0.0002589898,0.001325537,0.0009664094,0.000574053,0.0006297928,0.0001920044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005931349,"about_ca_system_score_gemma":0.0003810192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005090344,"about_ca_topic_score_gemma":0.0005229012,"domain_scores_codex":[0.9997415,0.00002928118,0.00001405063,0.00008139032,0.00008352179,0.00005020164],"domain_scores_gemma":[0.9995433,0.0000550994,0.000161831,0.00005903173,0.00006964831,0.0001110148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000313467,0.0000305155,0.006718506,0.0001203931,0.00001752448,0.0003782778,0.0003491036,0.0008536052,0.938117,0.02891905,0.0005461886,0.02363646],"study_design_scores_gemma":[0.0001450099,0.001743081,0.05849118,0.00008326536,0.00008424454,0.004196578,0.0008168372,0.01406194,0.8262197,0.03907924,0.05489516,0.0001837846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9391969,0.002699293,0.0464012,0.0008326824,0.0001800737,0.00004543551,0.0001819118,0.0003929674,0.01006955],"genre_scores_gemma":[0.9905934,0.0008027927,0.00656889,0.0001914674,0.00003505748,0.00001641569,0.00009651209,0.00002283012,0.001672713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000661707,"threshold_uncertainty_score":0.004303575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03460456461670686,"score_gpt":0.2499230488036281,"score_spread":0.2153184841869212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}