{"id":"W4366372020","doi":"10.1016/j.tips.2023.03.008","title":"Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges","year":2023,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Eye Institute","keywords":"Wnt signaling pathway; Therapeutic modalities; Catenin; Neuroscience; Treatment modality; Signal transduction; Medicine; Computational biology; Cancer research; Biology; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009841988,0.001104748,0.001540164,0.001351277,0.000217549,0.001340308,0.001145119,0.001409544,0.003539075],"category_scores_gemma":[0.0008041242,0.0003232854,0.0005381308,0.001343526,0.0005458424,0.001447296,0.000609026,0.003065488,0.002627063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008150592,"about_ca_system_score_gemma":0.001051007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009788078,"about_ca_topic_score_gemma":0.002294434,"domain_scores_codex":[0.9998097,0.00002811166,0.00002194565,0.000033664,0.00007685679,0.0000298143],"domain_scores_gemma":[0.9996775,0.0001335879,0.0000382178,0.000009657797,0.00009932704,0.00004173877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002109507,0.0001166262,0.0001385252,0.007731115,0.00008922593,0.0001643725,0.00003196508,0.000419198,0.005017516,0.005445501,0.04335706,0.937278],"study_design_scores_gemma":[0.00007022643,0.0001568744,0.0005486566,0.001492355,0.0001336886,0.000612702,0.00003248109,0.0001654306,0.001152569,0.002003695,0.9936116,0.00001973237],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001352792,0.9980488,0.0002567383,0.0004691095,0.0002968527,0.000004609546,0.0000243515,0.00001314805,0.0007511985],"genre_scores_gemma":[0.0007730729,0.9974244,0.0003249545,0.0003989331,0.0002200145,0.00001016394,0.00004664652,0.000002768232,0.000799191],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003539075,"threshold_uncertainty_score":0.01183945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3804907370105601,"score_gpt":0.4221713655869404,"score_spread":0.04168062857638033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}