{"id":"W4366392435","doi":"10.1002/2211-5463.13614","title":"Robust formation of optimal single spheroids towards cost‐effective <i>in vitro</i> three‐dimensional tumor models","year":2023,"lang":"en","type":"article","venue":"FEBS Open Bio","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Trent University; Nottingham Trent University","keywords":"Spheroid; In vivo; Confocal microscopy; Cell culture; In vitro; Cancer cell; Cell biology; 3D cell culture; Chemistry; Cell; Cellular pathology; Biology; Cancer; Biophysics; Pathology; Medicine; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005741825,0.0005898727,0.0004981718,0.0003491216,0.0002612115,0.0006783653,0.0003691882,0.0006513263,0.001236394],"category_scores_gemma":[0.0003106363,0.0003496397,0.0004361901,0.0003123322,0.000292673,0.000401176,0.0004276306,0.0007253081,0.001220217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004438895,"about_ca_system_score_gemma":0.0003963806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006130817,"about_ca_topic_score_gemma":0.001434859,"domain_scores_codex":[0.999674,0.00006926195,0.00004712402,0.00007480916,0.00009531715,0.00003953588],"domain_scores_gemma":[0.9997711,0.00004477636,0.00005625744,0.0000492246,0.00005065263,0.00002801851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000268764,0.00001870497,0.00007048708,0.0000786695,0.000004475839,0.00005608375,0.000041796,0.0007594567,0.9961902,0.0004557968,0.0003029145,0.001994541],"study_design_scores_gemma":[0.000005056762,0.00009893772,0.0004337118,0.00001215966,0.000009798862,0.0001295564,0.00001948846,0.003654131,0.9885306,0.00009645689,0.007001142,0.000009000563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4343196,0.004562358,0.5401493,0.0006397338,0.0003875731,0.001076399,0.00600432,0.002413526,0.01044708],"genre_scores_gemma":[0.6487937,0.004553882,0.3332162,0.0001556307,0.00003772711,0.001317149,0.004720261,0.0004199328,0.006785395],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001236394,"threshold_uncertainty_score":0.004136086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05702515803517138,"score_gpt":0.2968220469968447,"score_spread":0.2397968889616733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}