{"id":"W4366405937","doi":"10.1089/genbio.2023.0008","title":"Engineering T Cell Development for the Next Generation of Stem Cell-Derived Immunotherapies","year":2023,"lang":"en","type":"review","venue":"GEN Biotechnology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Manitoba; CancerCare Manitoba; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Stem Cell Network","keywords":"Induced pluripotent stem cell; Stem cell; Cell therapy; Immunotherapy; T cell; Computer science; Medicine; Computational biology; Biology; Immunology; Immune system; Cell biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005789685,0.0006095661,0.0006508479,0.001194285,0.0001606611,0.0007708512,0.0005732043,0.0009833946,0.002814933],"category_scores_gemma":[0.0003705007,0.0002086166,0.0003699714,0.0008503914,0.0003622069,0.001060479,0.0005295905,0.00166934,0.001894673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000517024,"about_ca_system_score_gemma":0.0007344833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004015842,"about_ca_topic_score_gemma":0.0007853167,"domain_scores_codex":[0.9998485,0.00002463899,0.00001352252,0.00002199685,0.00007187009,0.00001956386],"domain_scores_gemma":[0.9998631,0.00006630331,0.00001829645,0.000004762755,0.00003236022,0.00001510235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005969312,0.0001040086,0.000117173,0.009028763,0.00004623918,0.0002174396,0.00004966174,0.0008137436,0.01426442,0.013178,0.01553256,0.9465885],"study_design_scores_gemma":[0.00001959061,0.0001431852,0.0002749913,0.001356029,0.00004666418,0.0007968984,0.00003222957,0.0002306959,0.004115841,0.003186167,0.9897838,0.00001386949],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004797743,0.9957328,0.001055639,0.0003927191,0.0002520495,0.00001230203,0.00001974125,0.00001853464,0.002036287],"genre_scores_gemma":[0.001999045,0.9955095,0.0008934779,0.0002889119,0.0001410033,0.00001699932,0.000040307,0.000003662482,0.001107204],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002814933,"threshold_uncertainty_score":0.009416819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.174436808023777,"score_gpt":0.3386897575866703,"score_spread":0.1642529495628934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}