{"id":"W4366427874","doi":"10.3389/fimmu.2023.1181014","title":"Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Ottawa Hospital; University of Ottawa","funders":"Health Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Mitacs; University of Ottawa; Ovarian Cancer Canada; Terry Fox Research Institute; Australian Government; Natural Sciences and Engineering Research Council of Canada; Ottawa Hospital Research Institute","keywords":"Oncolytic virus; Immune system; Trastuzumab emtansine; Trastuzumab; Immunotherapy; Cancer research; Medicine; Vesicular stomatitis virus; Cancer; Immunology; Breast cancer; Antibody; Virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006429342,0.001356397,0.0005768863,0.001119624,0.000371161,0.0004988344,0.0005988762,0.00124974,0.005758756],"category_scores_gemma":[0.000142748,0.0004507098,0.0006437694,0.0005453063,0.0004297766,0.0005198816,0.0002653474,0.002210937,0.002015695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006873675,"about_ca_system_score_gemma":0.0004683859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007825281,"about_ca_topic_score_gemma":0.001063914,"domain_scores_codex":[0.999431,0.0000746091,0.0000662356,0.0001576896,0.0001602516,0.0001102264],"domain_scores_gemma":[0.9997274,0.00003712721,0.00007191068,0.00004904635,0.00004032124,0.00007426579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008327189,0.000735289,0.0002821471,0.0001136339,0.00002607398,0.0001547562,0.00004986013,0.000263202,0.9948191,0.000572984,0.0005771044,0.001573089],"study_design_scores_gemma":[0.0003025511,0.004802694,0.002248881,0.0000378548,0.00009448483,0.001234406,0.00007355328,0.001546702,0.9739612,0.000228605,0.01544876,0.0000203014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506226,0.004316172,0.0188479,0.001042033,0.0007680965,0.001694417,0.01131499,0.0008223566,0.01057162],"genre_scores_gemma":[0.9330979,0.004114658,0.01754519,0.0004879729,0.00009751401,0.002610988,0.00987579,0.0002107414,0.03195928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005758756,"threshold_uncertainty_score":0.019265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09414800290936359,"score_gpt":0.3952059300351664,"score_spread":0.3010579271258028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}