{"id":"W4366430367","doi":"10.1016/j.molmed.2023.03.008","title":"AMPK is mitochondrial medicine for neuromuscular disorders","year":2023,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Economic Development, Job Creation and Trade; Institute of Musculoskeletal Health and Arthritis; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Muscular Dystrophy Canada","keywords":"Spinal muscular atrophy; Duchenne muscular dystrophy; AMPK; SMA*; Myotonic dystrophy; Neuromuscular disease; Medicine; Neuroscience; Muscular dystrophy; Neuromuscular junction; Protein kinase A; Bioinformatics; Biology; Disease; Internal medicine; Genetics; Kinase; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004756901,0.0008025285,0.0009308547,0.001621671,0.0003511425,0.001231677,0.0008206188,0.00141017,0.006733881],"category_scores_gemma":[0.0005849768,0.0002174973,0.000405378,0.001120892,0.0005130011,0.001505794,0.0009569702,0.002643047,0.00569118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005636106,"about_ca_system_score_gemma":0.0007026082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004138302,"about_ca_topic_score_gemma":0.0008361026,"domain_scores_codex":[0.9998354,0.00002816262,0.00002138869,0.00003492103,0.00005718875,0.00002295797],"domain_scores_gemma":[0.9997914,0.00007816708,0.00002943401,0.00001171608,0.00005543193,0.00003379369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001060381,0.00007728009,0.0001029609,0.0096757,0.00008341035,0.0002381907,0.00005152695,0.0002181918,0.00286008,0.01069571,0.05735077,0.9185401],"study_design_scores_gemma":[0.000008375382,0.0000400283,0.0001816654,0.000982982,0.00003022916,0.0005143642,0.00001734351,0.00003351118,0.0003221867,0.001854268,0.9960077,0.000007287943],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001120939,0.9958056,0.0002622132,0.0007927523,0.0009815207,0.000006492284,0.00002613657,0.00001886245,0.00199423],"genre_scores_gemma":[0.0009700426,0.995111,0.0003272903,0.0006148045,0.0006365819,0.000009568806,0.00005604838,0.000005183087,0.002269483],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006733881,"threshold_uncertainty_score":0.0225271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04748510675135956,"score_gpt":0.3821461872245405,"score_spread":0.3346610804731809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}