{"id":"W4366430367","doi":"10.1016/j.molmed.2023.03.008","title":"AMPK is mitochondrial medicine for neuromuscular disorders","year":2023,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Economic Development, Job Creation and Trade; Institute of Musculoskeletal Health and Arthritis; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Muscular Dystrophy Canada","keywords":"Spinal muscular atrophy; Duchenne muscular dystrophy; AMPK; SMA*; Myotonic dystrophy; Neuromuscular disease; Medicine; Neuroscience; Muscular dystrophy; Neuromuscular junction; Protein kinase A; Bioinformatics; Biology; Disease; Internal medicine; Genetics; Kinase; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003674952,0.0008291483,0.002079598,0.0007360366,0.00008678227,0.000006392038,0.0007325622,0.000848001,0.0002213218],"category_scores_gemma":[0.0005820112,0.0006499311,0.0007264922,0.0009460296,0.000565893,0.000003390388,0.0001893148,0.00045193,0.00002451375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002909428,"about_ca_system_score_gemma":0.0001154451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008970085,"about_ca_topic_score_gemma":0.0001236764,"domain_scores_codex":[0.9963164,0.0002981205,0.001025686,0.001325011,0.0003387111,0.0006960308],"domain_scores_gemma":[0.9981267,0.0001247013,0.0003660056,0.001135436,0.000058634,0.0001885216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001684617,0.0001136942,0.000002867971,0.005576893,0.0006419353,0.00004272144,0.0001239189,0.0000132449,0.002690162,0.0003438818,0.07622541,0.9140568],"study_design_scores_gemma":[0.002522273,0.001149495,0.00001434568,0.002849017,0.0007729791,0.000009560727,0.00003720425,0.00001117653,0.0000249601,0.0008032447,0.9912209,0.0005848418],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003798256,0.9934357,0.001336963,0.001240419,0.001411246,0.0009379057,0.00007131173,0.00005309358,0.001475394],"genre_scores_gemma":[0.00003360474,0.9905781,0.0001716012,0.001000277,0.001300888,0.0006409648,0.00420811,0.0002169326,0.001849573],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9149955,"threshold_uncertainty_score":0.9995952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04748510675135956,"score_gpt":0.3821461872245405,"score_spread":0.3346610804731809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}