{"id":"W4366465515","doi":"10.1139/cjc-2022-0236","title":"New bis(thieno[2,3-<i>b</i>]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Enterococcus faecalis; Chemistry; Minimum inhibitory concentration; Staphylococcus aureus; Piperazine; Minimum bactericidal concentration; Antibacterial activity; Escherichia coli; Microbiology; Pseudomonas aeruginosa; Antimicrobial; Sonication; Linezolid; Ciprofloxacin; Bacteria; Organic chemistry; Biology; Antibiotics; Vancomycin; Biochemistry; Chromatography","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000862579,0.0003760744,0.0002020187,0.0001784109,0.0001014499,0.0001694211,0.0002712743,0.0003415325,0.0009716738],"category_scores_gemma":[0.0001132064,0.0001765604,0.0001658364,0.0001672901,0.0001168331,0.0002438847,0.0001735183,0.0003841729,0.0002744314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001910677,"about_ca_system_score_gemma":0.00008996637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003231911,"about_ca_topic_score_gemma":0.0008284773,"domain_scores_codex":[0.9999413,0.00000919014,0.000004059637,0.0000127218,0.0000176733,0.00001507888],"domain_scores_gemma":[0.9999416,0.000007780836,0.00002405815,0.000003936482,0.00001063568,0.00001202224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004653368,0.0000210266,0.00005919849,0.0001224912,0.000008368289,0.00007916884,0.00002112711,0.0002383393,0.9973657,0.0001719243,0.0000579542,0.001808315],"study_design_scores_gemma":[0.00001617531,0.0007210312,0.001567498,0.00001237765,0.00002405283,0.0003216472,0.00002853562,0.001113354,0.9920684,0.00004369621,0.004070038,0.00001324584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828111,0.003624546,0.009181145,0.00009245236,0.00004628509,0.00007367817,0.000268186,0.0001429338,0.003759711],"genre_scores_gemma":[0.9853032,0.001959991,0.008296351,0.00006348527,0.00001163417,0.0000982816,0.0002838302,0.00001601734,0.003967336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009716738,"threshold_uncertainty_score":0.003250599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009475743829109437,"score_gpt":0.2064106237953461,"score_spread":0.1969348799662367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}