{"id":"W4366483329","doi":"10.1016/j.bmc.2023.117275","title":"Current and emerging therapies for Achondroplasia: The dawn of precision medicine","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stornoway Diamond (Canada)","funders":"","keywords":"Achondroplasia; Fibroblast growth factor receptor 3; Dwarfism; Disease; Clinical trial; Missense mutation; Bioinformatics; Medicine; Fibroblast growth factor; Internal medicine; Phenotype; Receptor; Gene; Pediatrics; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003930519,0.0001381381,0.0001743655,0.00003138407,0.0001050975,0.000005478065,0.0002346111,0.00008564215,0.0000942737],"category_scores_gemma":[0.0008711201,0.00009132858,0.00004522803,0.0002254191,0.0003261612,0.000002329225,0.0001542693,0.0001209574,0.000002452081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000103364,"about_ca_system_score_gemma":0.00007197751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009152192,"about_ca_topic_score_gemma":0.00000490706,"domain_scores_codex":[0.9989691,0.00002984072,0.0002051732,0.0003059946,0.0002592108,0.0002306711],"domain_scores_gemma":[0.9993169,0.0001298212,0.00007829795,0.0002705445,0.0001361411,0.00006831647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008020153,0.00001751122,0.001358566,0.0001680448,0.00004895512,8.864837e-7,0.0005408808,2.062059e-7,0.9603955,0.00000823758,0.007160573,0.03022045],"study_design_scores_gemma":[0.001791547,0.0003828861,0.00904279,0.0001909579,0.00006763891,0.00003395312,0.006197736,0.0001699909,0.8615727,0.0004002288,0.1199326,0.0002169333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685052,0.02774501,0.0003775387,0.002743096,0.0001376885,0.000287472,0.00001828637,0.00001739344,0.0001683269],"genre_scores_gemma":[0.9959167,0.003014552,0.00001428388,0.00002786513,0.0003978311,0.00003935565,0.0001015718,0.00002220952,0.0004655859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.112772,"threshold_uncertainty_score":0.3724272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260090092682402,"score_gpt":0.3387862592419086,"score_spread":0.3127772499736685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}