{"id":"W4366483329","doi":"10.1016/j.bmc.2023.117275","title":"Current and emerging therapies for Achondroplasia: The dawn of precision medicine","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stornoway Diamond (Canada)","funders":"","keywords":"Achondroplasia; Fibroblast growth factor receptor 3; Dwarfism; Disease; Clinical trial; Missense mutation; Bioinformatics; Medicine; Fibroblast growth factor; Internal medicine; Phenotype; Receptor; Gene; Pediatrics; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006221054,0.0007237769,0.001866813,0.001407426,0.000861512,0.004491816,0.001196642,0.002667062,0.004923053],"category_scores_gemma":[0.004630909,0.0002713783,0.0007949584,0.0008131756,0.004591241,0.007172752,0.002151703,0.006634711,0.001017792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002016596,"about_ca_system_score_gemma":0.003016787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009537447,"about_ca_topic_score_gemma":0.001721956,"domain_scores_codex":[0.9986557,0.0003923045,0.00009640884,0.0002084336,0.0004787208,0.0001684429],"domain_scores_gemma":[0.9952062,0.002990184,0.0002962066,0.0002503009,0.0008487501,0.0004082952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008864891,0.0004825192,0.001618202,0.004516293,0.000215877,0.0006068913,0.000525824,0.001871238,0.01677481,0.2245141,0.05430054,0.6936872],"study_design_scores_gemma":[0.0003086959,0.001086417,0.002013965,0.003028065,0.0002105155,0.001408279,0.001002741,0.00266499,0.006485857,0.2826072,0.6990632,0.0001200461],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003084705,0.9177051,0.01164185,0.05862385,0.002950211,0.00002656996,0.00009759149,0.0001470428,0.005723143],"genre_scores_gemma":[0.062412,0.8913025,0.0143892,0.01987271,0.008740472,0.00007979599,0.0001709176,0.00005106251,0.002981405],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006221054,"threshold_uncertainty_score":0.03290045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260090092682402,"score_gpt":0.3387862592419086,"score_spread":0.3127772499736685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}