{"id":"W4366495712","doi":"10.1093/pch/pxac122","title":"Ensuring access to innovative therapies for children, adolescents, and young adults across Canada: The single patient study experience","year":2023,"lang":"en","type":"review","venue":"Paediatrics & Child Health","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Women's College Hospital; Government of Alberta; University of Alberta; BC Children's Hospital; C17 Council; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Health Canada; Hospital for Sick Children; Bayer Canada; BC Children's Hospital","keywords":"Medicine; Expanded access; Limiting; Clinical trial; Family medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007981801,0.0004637334,0.0013917,0.00007582317,0.001114068,0.0001287927,0.0003522192,0.00008863917,0.000002253781],"category_scores_gemma":[0.0007703737,0.0002861321,0.0001112079,0.001487952,0.00005521709,0.0000945686,0.0005955052,0.000763812,0.000002306069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000495806,"about_ca_system_score_gemma":0.0006655818,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.07790811,"about_ca_topic_score_gemma":0.1196946,"domain_scores_codex":[0.9967537,0.0002233943,0.0009328729,0.0006909642,0.000584584,0.0008144857],"domain_scores_gemma":[0.9977307,0.0006183919,0.0006940219,0.0003541101,0.0002579276,0.0003448052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001034675,0.0003172854,0.02056555,0.008383752,0.0003063691,0.000007867681,0.01283389,2.3709e-7,3.621089e-9,0.000003465033,0.002071394,0.9554067],"study_design_scores_gemma":[0.001220495,0.001028867,0.1031935,0.006570034,0.0004034067,0.00003610555,0.006421838,0.00000170138,2.340296e-7,0.000001907541,0.8806419,0.0004800675],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01399304,0.9729708,0.000008374718,0.002733608,0.0008346383,0.008900422,0.0004895851,0.00005217243,0.00001739017],"genre_scores_gemma":[0.03731554,0.9575338,0.00002166393,0.003451933,0.0008221856,0.0007185904,0.0000568346,0.00007171832,0.000007707175],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9549267,"threshold_uncertainty_score":0.9999591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231060686956678,"score_gpt":0.4405985375011718,"score_spread":0.317492468805504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}