{"id":"W4366496023","doi":"10.1007/s11095-023-03472-6","title":"Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics","year":2023,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"U.S. Food and Drug Administration; Hamilton Health Sciences Foundation","keywords":"Fluticasone propionate; Pharmacokinetics; Bioequivalence; Mucociliary clearance; Dry-powder inhaler; Population; Pharmacology; Absorption (acoustics); Bioavailability; Medicine; Chemistry; Inhalation; Inhaler; Lung; Anesthesia; Internal medicine; Asthma; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004679059,0.0002485955,0.0004013572,0.0003412306,0.0001854175,0.0006141441,0.0001449496,0.000472306,0.001295382],"category_scores_gemma":[0.0007374127,0.000332609,0.0002679175,0.0001824715,0.0004461197,0.0003270239,0.0001568212,0.0004048951,0.0003478258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002790207,"about_ca_system_score_gemma":0.0003622154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001690189,"about_ca_topic_score_gemma":0.001158409,"domain_scores_codex":[0.999686,0.00008183761,0.00001257883,0.0001055532,0.00007092411,0.0000430387],"domain_scores_gemma":[0.9996338,0.0001232392,0.0001124979,0.00004527747,0.00004311089,0.00004203061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0305486,0.0006388993,0.1516982,0.0003274232,0.0003619216,0.001819059,0.0006985596,0.00160975,0.7454786,0.0006996983,0.0009665861,0.06515259],"study_design_scores_gemma":[0.0002816425,0.006599382,0.8903887,0.00001994543,0.0002921137,0.005529645,0.0004879344,0.006779135,0.08759673,0.0004767195,0.001502162,0.00004588593],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950781,0.00168211,0.002084993,0.00004732824,0.00001065282,0.00003951598,0.0002080366,0.00004116025,0.0008081359],"genre_scores_gemma":[0.998198,0.0004109679,0.0006070685,0.00005688177,0.00001415125,0.00002653941,0.0001742454,0.00001562309,0.0004965729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001690189,"threshold_uncertainty_score":0.004333496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0938101301099307,"score_gpt":0.4436765467331564,"score_spread":0.3498664166232257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}