{"id":"W4366496785","doi":"10.1016/j.ejca.2023.04.014","title":"Circulating tumour DNA kinetics in recurrent/metastatic head and neck squamous cell cancer patients","year":2023,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Ontario Ministry of Research, Innovation and Science; Government of Ontario; Public Health Agency; Princess Margaret Cancer Foundation","keywords":"Squamous cell cancer; Head and neck; Medicine; Head and neck cancer; Oncology; Cancer; Kinetics; DNA; Internal medicine; Cancer research; Surgery; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002577582,0.0001386127,0.0001763359,0.0001006656,0.00003576096,0.00003560262,0.0001447249,0.00002062209,0.00001802524],"category_scores_gemma":[0.0001397975,0.0001334143,0.0000642743,0.000164645,0.00003471421,0.000005761626,0.0001005551,0.0001407854,0.000004839427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004674431,"about_ca_system_score_gemma":0.00009374375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003156546,"about_ca_topic_score_gemma":0.0001624698,"domain_scores_codex":[0.9988913,0.0001032081,0.0004238531,0.0001812565,0.0001646188,0.0002357666],"domain_scores_gemma":[0.9992954,0.00002760731,0.0002935911,0.0001058661,0.0001607991,0.0001168043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006131252,0.0005888529,0.2806353,0.0003490282,0.0001281716,0.0007121692,0.001461939,0.01776853,0.5045723,0.00001409796,0.02644808,0.1667084],"study_design_scores_gemma":[0.008247831,0.002437738,0.8606284,0.0004379736,0.0001318117,0.00003629557,0.0002114546,0.0005082949,0.03286422,0.00005550506,0.09376214,0.0006782979],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922581,0.006182046,0.00002980529,0.0001695376,0.0006041285,0.00008971955,0.00005241676,0.000003688033,0.0006105096],"genre_scores_gemma":[0.9954787,0.00355008,0.0001505331,0.0002160253,0.000418761,0.00000325742,0.00001496386,0.00004146715,0.000126152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5799931,"threshold_uncertainty_score":0.5440477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0160783280508068,"score_gpt":0.2699332835673543,"score_spread":0.2538549555165475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}