{"id":"W4366525787","doi":"10.1136/gutjnl-2023-329689","title":"Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis","year":2023,"lang":"en","type":"review","venue":"Gut","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Inflammatory Bowel and Immunobiology Research Institute; Cedars-Sinai Medical Center; Francis Crick Institute; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Crohn's disease; Complement factor B; Complement system; Immunology; Factor H; Coding (social sciences); Medicine; Biology; Disease; Virology; Internal medicine; Antibody; Mathematics; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009231247,0.0008005846,0.0005939694,0.0006896637,0.0003634835,0.0005041031,0.0003338445,0.000674419,0.002015617],"category_scores_gemma":[0.001496066,0.0002016722,0.001267583,0.001181421,0.0003735352,0.0001609388,0.0003123534,0.0004102411,0.000142398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177762,"about_ca_system_score_gemma":0.0001733335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003238356,"about_ca_topic_score_gemma":0.002457276,"domain_scores_codex":[0.999323,0.000176435,0.00006684669,0.00027284,0.0001038254,0.00005707518],"domain_scores_gemma":[0.9989356,0.0004494061,0.0003680986,0.00008617556,0.00006091724,0.00009975379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00863634,0.0001298801,0.9282596,0.0004742822,0.009930626,0.001190535,0.00009058815,0.00113375,0.03733638,0.0002164344,0.0004685917,0.01213299],"study_design_scores_gemma":[0.0003862839,0.0007194698,0.9852228,0.0000820726,0.005140157,0.002098872,0.0000580534,0.001887523,0.003202881,0.0002614039,0.0009222582,0.00001832879],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9938781,0.00412483,0.0009804537,0.0001295741,0.00003063192,0.0000121008,0.0005415587,0.00002371285,0.0002789963],"genre_scores_gemma":[0.9988189,0.000382764,0.0003500041,0.00003898351,0.0000243858,0.000005548583,0.0002304594,0.000003536385,0.0001454104],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003238356,"threshold_uncertainty_score":0.006742895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03668892790939476,"score_gpt":0.3030811372013669,"score_spread":0.2663922092919721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}