{"id":"W4366525787","doi":"10.1136/gutjnl-2023-329689","title":"Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis","year":2023,"lang":"en","type":"review","venue":"Gut","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Inflammatory Bowel and Immunobiology Research Institute; Cedars-Sinai Medical Center; Francis Crick Institute; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Crohn's disease; Complement factor B; Complement system; Immunology; Factor H; Coding (social sciences); Medicine; Biology; Disease; Virology; Internal medicine; Antibody; Mathematics; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00027257,0.0004838074,0.000796774,0.0001523138,0.0001560085,0.00009547593,0.0001934768,0.0002106167,0.00002131724],"category_scores_gemma":[0.0003062583,0.0004272501,0.0001976394,0.0001408792,0.00007357884,0.000004933676,0.0002187928,0.0001313162,0.000007832837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001117465,"about_ca_system_score_gemma":0.0003958421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008738848,"about_ca_topic_score_gemma":0.0005739499,"domain_scores_codex":[0.997797,0.0002539926,0.0005049809,0.0007866134,0.000181729,0.0004757044],"domain_scores_gemma":[0.9987188,0.00007329328,0.0002795707,0.0004006823,0.00006618193,0.0004614629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01358345,0.002411022,0.228914,0.1254756,0.0187021,0.02134715,0.003083095,0.00009383471,0.003618344,0.0002182417,0.03511805,0.5474351],"study_design_scores_gemma":[0.005429989,0.0006103691,0.8817531,0.00660549,0.004050297,0.0000330016,0.00007992276,0.0003278592,0.00004156848,0.00002943448,0.09884279,0.002196194],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6236405,0.3564587,0.0002325385,0.00002555866,0.00009634307,0.004237193,0.01524488,0.0000499292,0.00001427327],"genre_scores_gemma":[0.1422999,0.8530337,0.0004100824,0.0002842722,0.0002957165,0.001343176,0.001890669,0.0002461614,0.000196334],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6528391,"threshold_uncertainty_score":0.9998179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03668892790939476,"score_gpt":0.3030811372013669,"score_spread":0.2663922092919721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}