{"id":"W4366549929","doi":"10.1038/s41467-023-37732-1","title":"Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Directorate for Biological Sciences; Vetenskapsrådet; Biotechnology and Biological Sciences Research Council; ZonMw; Universitair Medisch Centrum Utrecht; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universität Duisburg-Essen; Deutsche Forschungsgemeinschaft; European Commission; Centers for Disease Control and Prevention; Imperial College London","keywords":"Sepsis; Pathogenesis; Streptococcus pyogenes; Bacterial adhesin; Immunology; Biology; Microbiology; Medicine; Gene; Virulence; Staphylococcus aureus; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007788774,0.0001512263,0.0001549895,0.0001000291,0.00009190148,0.0001527159,0.0001110565,0.0002600138,0.0005814385],"category_scores_gemma":[0.0001138637,0.00007341099,0.000160555,0.00007197987,0.0001397083,0.00008046917,0.0001899102,0.0002387822,0.0001552103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001512006,"about_ca_system_score_gemma":0.0001314189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005601014,"about_ca_topic_score_gemma":0.000401362,"domain_scores_codex":[0.9999378,0.00001309328,0.000002777861,0.00001182085,0.00001660532,0.00001803939],"domain_scores_gemma":[0.9999577,0.000006065739,0.00001594778,0.000003069257,0.000003625205,0.00001358162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001619466,0.00001987191,0.004673465,0.00006029203,0.00001677158,0.0008204037,0.00004578922,0.0001961124,0.9895086,0.0002288566,0.0001744277,0.004093521],"study_design_scores_gemma":[0.00005049845,0.000656458,0.1504676,0.00004327005,0.00006401489,0.008688818,0.0002418649,0.009452634,0.8202464,0.0006287916,0.009433929,0.00002569829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962237,0.001919206,0.001041503,0.0001198037,0.00001197405,0.000007466968,0.00005406341,0.00002293784,0.000599332],"genre_scores_gemma":[0.9979874,0.0005222963,0.0008361002,0.00008920724,0.000005550507,0.000004219338,0.00009690856,0.000002512802,0.0004558005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005814385,"threshold_uncertainty_score":0.001945138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421311847535523,"score_gpt":0.3624534957118781,"score_spread":0.3282403772365229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}