{"id":"W4366549941","doi":"10.18632/aging.204668","title":"How can we modulate aging through nutrition and physical exercise? An epigenetic approach","year":2023,"lang":"en","type":"review","venue":"Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"","keywords":"Epigenetics; Histone; Chromatin; Biology; DNA methylation; Heterochromatin; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001635283,0.0003974028,0.0007091806,0.00008789695,0.0001461634,0.000161605,0.0002017369,0.0002707642,4.425805e-7],"category_scores_gemma":[0.00001796918,0.0003748873,0.0002157098,0.0001998196,0.00006571622,0.00000920025,0.0001699963,0.0002064506,0.000002787353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002235401,"about_ca_system_score_gemma":0.00005825625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003116104,"about_ca_topic_score_gemma":0.00001030648,"domain_scores_codex":[0.9982947,0.0001419665,0.0002555685,0.0007882605,0.0001657674,0.0003537945],"domain_scores_gemma":[0.9991493,0.00002089141,0.0001888039,0.0004878336,0.00004675934,0.000106393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001699755,0.00008155678,0.000008275445,0.008977793,0.00009666707,0.000005473365,0.0002802259,0.00003126422,0.002165927,0.00004589219,0.0000215327,0.9882837],"study_design_scores_gemma":[0.0005485557,0.000179703,0.00002511625,0.008418982,0.001061887,0.00001683917,0.0003109675,0.001027712,0.006681457,0.00333302,0.976919,0.001476784],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002940059,0.9942142,0.001890351,0.00006311081,0.0001213682,0.0006112003,0.00003833311,0.00004123345,0.00008013677],"genre_scores_gemma":[0.00597856,0.989969,0.001450074,0.00001019546,0.0008343293,0.0001526576,0.001123855,0.0001188526,0.0003624418],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9868069,"threshold_uncertainty_score":0.9998703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06209967994781219,"score_gpt":0.3338328102961413,"score_spread":0.2717331303483291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}