{"id":"W4366550103","doi":"10.1101/2023.04.19.537542","title":"Tracking insulin- and glucagon-expressing bihormonal cells during differentiation using an <i>INSULIN</i> and <i>GLUCAGON</i> double reporter human embryonic stem cell line","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; University of Alberta; BC Children's Hospital","keywords":"Glucagon; Insulin; Embryonic stem cell; Cell biology; Biology; Green fluorescent protein; Cell culture; Stem cell; Beta cell; Alpha cell; Cellular differentiation; Reporter gene; Enteroendocrine cell; Endocrinology; Internal medicine; Hormone; Gene expression; Endocrine system; Islet; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002486909,0.0001981336,0.0001638127,0.0002075949,0.0001290699,0.0003847886,0.0001461495,0.0002084422,0.001055258],"category_scores_gemma":[0.00008604216,0.0001495344,0.0001617275,0.0001627209,0.0001533286,0.0001890756,0.0002823104,0.0004940079,0.0007007622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001680101,"about_ca_system_score_gemma":0.0001716773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005218767,"about_ca_topic_score_gemma":0.0006049405,"domain_scores_codex":[0.9999121,0.000007944695,0.000008951376,0.0000288504,0.00003110596,0.0000110351],"domain_scores_gemma":[0.9999225,0.00001626251,0.00001606629,0.00001070783,0.00001365062,0.00002066936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001932426,0.000003374361,0.0002076383,0.00001189227,0.000001233613,0.00002227367,0.00002019743,0.00006277701,0.9981761,0.0001112068,0.00006281455,0.001301186],"study_design_scores_gemma":[0.000004622418,0.00003053777,0.001837897,0.00000446324,0.000005376271,0.0001626671,0.00001970846,0.001514571,0.9928966,0.00005973709,0.003459881,0.000004016543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8977137,0.001335868,0.09090187,0.000229289,0.0001313678,0.00008934456,0.001998995,0.0006569265,0.006942519],"genre_scores_gemma":[0.8840705,0.001622605,0.09683286,0.0001801329,0.0000282765,0.0001462381,0.00249526,0.0003229854,0.01430111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055258,"threshold_uncertainty_score":0.003530204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03620972343452471,"score_gpt":0.2502329964373716,"score_spread":0.2140232730028468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}