{"id":"W4366586230","doi":"10.1186/s12885-023-10851-0","title":"The use of Lutetium-177 PSMA radioligand therapy with high dose rate brachytherapy for locally recurrent prostate cancer after previous definitive radiation therapy: a randomized, single-institution, phase I/II study (ROADSTER).","year":2023,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; London Health Sciences Foundation","keywords":"Medicine; Prostate cancer; Brachytherapy; Radiation therapy; Radionuclide therapy; Prostate; Oncology; Cancer; Radiology; Nuclear medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003078156,0.001862376,0.002390586,0.0006153334,0.0005540248,0.001169927,0.001385137,0.001902349,0.004661059],"category_scores_gemma":[0.001777448,0.0009201703,0.002220029,0.0005288525,0.001612434,0.001287569,0.000538846,0.002999492,0.0008995068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009926694,"about_ca_system_score_gemma":0.002064568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008049123,"about_ca_topic_score_gemma":0.002411457,"domain_scores_codex":[0.9987074,0.0007457054,0.00007545471,0.0002391232,0.00009191436,0.000140345],"domain_scores_gemma":[0.9980775,0.0003672502,0.000654877,0.0002551199,0.00009143879,0.0005537932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8875033,0.0702486,0.002604224,0.0006691784,0.001448182,0.00008057522,0.0001810969,0.001184915,0.01140377,0.0001266676,0.0008220106,0.0237275],"study_design_scores_gemma":[0.5811921,0.4134496,0.002498814,0.00002272057,0.0005045775,0.00008270588,0.00003457097,0.0003595287,0.001237178,0.00007073642,0.0005252323,0.0000221758],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930196,0.001059665,0.0004889044,0.0002081987,0.0001320479,0.003836388,0.0004254449,0.00009230299,0.000737534],"genre_scores_gemma":[0.9854278,0.001473959,0.002879147,0.0007741281,0.0002440804,0.006142807,0.0008095002,0.00005392514,0.002194638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004661059,"threshold_uncertainty_score":0.0162791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08026402452094256,"score_gpt":0.3612973629425614,"score_spread":0.2810333384216189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}