{"id":"W4366586230","doi":"10.1186/s12885-023-10851-0","title":"The use of Lutetium-177 PSMA radioligand therapy with high dose rate brachytherapy for locally recurrent prostate cancer after previous definitive radiation therapy: a randomized, single-institution, phase I/II study (ROADSTER).","year":2023,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; London Health Sciences Foundation","keywords":"Medicine; Prostate cancer; Brachytherapy; Radiation therapy; Radionuclide therapy; Prostate; Oncology; Cancer; Radiology; Nuclear medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009034746,0.0004313026,0.0008876314,0.0002059105,0.0004201143,0.0001185492,0.0001432716,0.0000925495,0.00005764301],"category_scores_gemma":[0.00009770075,0.0002278174,0.0002519551,0.0007059884,0.0005183863,0.0002610729,0.00003503873,0.000205673,0.000003928192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004106015,"about_ca_system_score_gemma":0.001298322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000624805,"about_ca_topic_score_gemma":0.0009914192,"domain_scores_codex":[0.9972041,0.0004329036,0.0006453174,0.0006075231,0.0004921468,0.000618009],"domain_scores_gemma":[0.9975494,0.0007337529,0.0003784313,0.0004738624,0.0007009846,0.0001636426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7082693,0.002086546,0.008255018,0.000145384,0.001855275,0.00004145502,0.007990797,0.000493168,0.001729284,0.00002981117,0.00110263,0.2680013],"study_design_scores_gemma":[0.8912033,0.02059564,0.01238655,0.001112511,0.0006993698,0.00001624609,0.0005390057,0.001634974,0.01824536,0.0001385268,0.05271567,0.0007128151],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454734,0.03710715,0.0002578342,0.001492939,0.0005262716,0.0145506,0.0004746517,0.0001047092,0.00001244177],"genre_scores_gemma":[0.870998,0.107045,0.0001189792,0.000334981,0.0003651413,0.01908141,0.0001583015,0.00008939414,0.001808744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2672885,"threshold_uncertainty_score":0.9290122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08026402452094256,"score_gpt":0.3612973629425614,"score_spread":0.2810333384216189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}