{"id":"W4366590730","doi":"10.1038/s43018-023-00547-6","title":"CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma","year":2023,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"McGill University; KWF Kankerbestrijding; Brain Tumor Funders' Collaborative","keywords":"Immunotherapy; Glioblastoma; Cytotoxic T cell; CD8; Cancer research; T cell; Immunology; Biology; Neuroscience; Cell biology; Medicine; Antigen; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008089154,0.0001503224,0.000203108,0.0001659981,0.0000726093,0.0002092285,0.00008346866,0.0001755349,0.001075596],"category_scores_gemma":[0.00008953049,0.00008676417,0.00009323328,0.00008588051,0.0001414545,0.00007227805,0.00008352088,0.0003378586,0.0001993235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001673944,"about_ca_system_score_gemma":0.0001025861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004747595,"about_ca_topic_score_gemma":0.00044505,"domain_scores_codex":[0.9999533,0.000007098668,0.000003906527,0.000007685394,0.000008471205,0.00001954327],"domain_scores_gemma":[0.9999515,0.000005854227,0.00001650522,0.00000495004,0.000006271554,0.00001497483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006535409,0.0001135132,0.004759448,0.00003417913,0.0000100412,0.0003351295,0.00002594395,0.0001242357,0.9869784,0.0001275448,0.0001910957,0.006646863],"study_design_scores_gemma":[0.0001458654,0.003090092,0.1502738,0.00003085797,0.00009238883,0.007146108,0.0002658836,0.004024689,0.8289964,0.0008611295,0.005057768,0.00001500396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979226,0.000592617,0.0007519978,0.00004975629,0.000009614454,0.00001618777,0.0000705863,0.00005391865,0.0005326699],"genre_scores_gemma":[0.9993374,0.0001740608,0.0001238416,0.00002007423,0.0000033211,0.000007907514,0.00004874488,0.000003420079,0.0002811518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075596,"threshold_uncertainty_score":0.003598213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007556071548584209,"score_gpt":0.2740659460874063,"score_spread":0.266509874538822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}