{"id":"W4366596010","doi":"10.1016/j.bbrc.2023.04.067","title":"Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells","year":2023,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Canadian Internet Registration Authority; Japan Agency for Medical Research and Development","keywords":"Human leukocyte antigen; Biology; Induced pluripotent stem cell; Humanized mouse; Immunology; Haematopoiesis; Janus kinase 3; Stem cell; Interleukin 12; Interleukin 21; Cancer research; Cell biology; Antigen; Cytotoxic T cell; T cell; Immune system; In vitro; Embryonic stem cell; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009339338,0.0009965673,0.0005312777,0.0007791533,0.0002832642,0.0007610165,0.0006674977,0.001147007,0.005688072],"category_scores_gemma":[0.0002709851,0.0002836391,0.0005586407,0.0002902599,0.0006603556,0.0007181242,0.0002863046,0.002729692,0.001601157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000368645,"about_ca_system_score_gemma":0.0004006206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003302094,"about_ca_topic_score_gemma":0.0003729233,"domain_scores_codex":[0.9993906,0.00007266595,0.00007283017,0.0001814742,0.0001684053,0.0001139543],"domain_scores_gemma":[0.9996272,0.00007589169,0.00009714243,0.00008699152,0.00004835282,0.00006433589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005652095,0.0005104434,0.0001697665,0.00009329604,0.00002018431,0.0001930521,0.00007851813,0.0004032586,0.9940354,0.001017373,0.0003256973,0.002587827],"study_design_scores_gemma":[0.0001069719,0.001376147,0.0004643211,0.00002223158,0.00006853473,0.0004334659,0.00005212793,0.00163519,0.9888816,0.0002093202,0.006739532,0.00001062057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.928827,0.002041494,0.05618462,0.0003708272,0.0007844117,0.001123839,0.003345111,0.001110052,0.00621261],"genre_scores_gemma":[0.9584496,0.001890603,0.02004292,0.0002780839,0.00007321558,0.001431528,0.00261755,0.0002617034,0.01495464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005688072,"threshold_uncertainty_score":0.01902848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1809811898549389,"score_gpt":0.3873932112505866,"score_spread":0.2064120213956477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}