{"id":"W4366598165","doi":"10.1186/s13223-023-00776-5","title":"Long term longitudinal follow-up of an AD-HIES cohort: the impact of early diagnosis and enrollment to IPINet centers on the natural history of Job’s syndrome","year":2023,"lang":"en","type":"article","venue":"Allergy Asthma and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Ministero della Salute","keywords":"Medicine; Incidence (geometry); Natural history; Mucocutaneous zone; Cohort; Pediatrics; Bronchiectasis; Primary immunodeficiency; Pneumonia; Internal medicine; Disease; Lung","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001439206,0.0002333117,0.0003008342,0.0008093516,0.0004707878,0.0007560314,0.000326438,0.0003758884,0.0008901462],"category_scores_gemma":[0.002983026,0.0001845784,0.0003716787,0.0007044778,0.0002223646,0.0006146096,0.0005249582,0.0005655874,0.0001831337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002946204,"about_ca_system_score_gemma":0.0003503023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004586935,"about_ca_topic_score_gemma":0.003980031,"domain_scores_codex":[0.999339,0.0001948098,0.00004847321,0.0001821033,0.00008901376,0.0001466033],"domain_scores_gemma":[0.9977733,0.0003780954,0.0008841386,0.0002920884,0.0002029204,0.0004694067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009956608,0.00002754528,0.9989157,0.000002031278,0.00002429713,0.0000762429,0.00004620593,0.00001349649,0.00009238767,0.00000751475,0.00003657379,0.0006584956],"study_design_scores_gemma":[0.000003983081,0.0001364522,0.9991866,0.000004104242,0.00002375912,0.0002456996,0.0001350684,0.0001020566,0.00003166805,0.00001024908,0.0001178658,0.000002406504],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993013,0.0001694991,0.00004308504,0.00003306577,0.000004254628,0.000003554177,0.0002183805,0.000001957192,0.0002248344],"genre_scores_gemma":[0.9993982,0.00008848857,0.00003657799,0.00001435975,0.000008971964,0.000004171388,0.0003641705,0.000001613698,0.00008336064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004586935,"threshold_uncertainty_score":0.009120464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02244357416412882,"score_gpt":0.2903839251537448,"score_spread":0.267940350989616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}