{"id":"W4366598548","doi":"10.1038/s41467-023-37705-4","title":"Characterization of a fold in TANGO1 evolved from SH3 domains for the export of bulky cargos","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Innovative Medicines Initiative; Research School, Ruhr University Bochum; Deutsche Forschungsgemeinschaft; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Diamond Light Source; McGill University; Ruhr-Universität Bochum; Bayer; European Commission; Pfizer; Bristol-Myers Squibb","keywords":"Endoplasmic reticulum; COPII; Golgi apparatus; Microscale thermophoresis; Vesicular Transport Proteins; Cell biology; SH3 domain; Biology; Mucin; Chemistry; Biophysics; Biochemistry; Peptide sequence; Gene; Phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Secretory pathway; N-terminus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006553247,0.0001359168,0.00008739701,0.00009704709,0.000106803,0.0001590931,0.000112362,0.0002072808,0.0004648831],"category_scores_gemma":[0.0001279887,0.00004698688,0.000183365,0.00009629395,0.0001279461,0.0001619817,0.0001130515,0.0002713442,0.0001390587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916717,"about_ca_system_score_gemma":0.0001053044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004758187,"about_ca_topic_score_gemma":0.0006103864,"domain_scores_codex":[0.9999833,0.000001772635,0.000001532578,0.000004670369,0.000004500986,0.000004213443],"domain_scores_gemma":[0.9999372,0.00001167948,0.00001546837,0.000004473656,0.00000512386,0.00002600722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00010208,0.00001084729,0.001734673,0.00002130546,0.000004321402,0.0002697189,0.00003092636,0.0001547609,0.9965708,0.0001470674,0.00001715137,0.0009364384],"study_design_scores_gemma":[0.00002631698,0.0003971051,0.125389,0.00002450275,0.00004267812,0.00302187,0.0001516264,0.006329128,0.8588344,0.000425787,0.0053336,0.00002397791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989945,0.0001751346,0.000433,0.00001824643,0.000002925181,0.000003160511,0.0001159024,0.000006355868,0.0002506521],"genre_scores_gemma":[0.9973096,0.0001083833,0.0009901188,0.00002974718,0.000003312636,0.000006650965,0.0006935889,0.000006921075,0.0008517363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004758187,"threshold_uncertainty_score":0.001555204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657217825757942,"score_gpt":0.2695040132573457,"score_spread":0.2529318349997663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}