{"id":"W4366599450","doi":"10.3390/curroncol30040323","title":"Metastatic Castration-Resistant Prostate Cancer, Immune Checkpoint Inhibitors, and Beyond","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Prostate cancer; Medicine; Pembrolizumab; Immunotherapy; Immune checkpoint; Cancer; PARP inhibitor; Oncology; Ipilimumab; Cancer research; Internal medicine; Poly ADP ribose polymerase; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002974093,0.0005388177,0.0009810621,0.00151799,0.0001849025,0.0007017302,0.0004992989,0.0005576563,0.003899614],"category_scores_gemma":[0.0003657835,0.0001849938,0.0004504517,0.001312132,0.0002146551,0.000769547,0.0004128237,0.001250694,0.001845765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004557009,"about_ca_system_score_gemma":0.0008627689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001783,"about_ca_topic_score_gemma":0.0026115,"domain_scores_codex":[0.9998983,0.00001766437,0.00001219279,0.0000159601,0.00004295487,0.0000130062],"domain_scores_gemma":[0.9998891,0.00004151939,0.00001922482,0.000003431166,0.00003383043,0.00001290703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009567293,0.00007591123,0.0001446508,0.02092259,0.0001127447,0.0001795364,0.00004524091,0.0003870896,0.00220428,0.003291582,0.03770442,0.9348362],"study_design_scores_gemma":[0.00001640461,0.00008961882,0.0005289906,0.002735202,0.00007739083,0.0007805492,0.00002669887,0.00006229128,0.0002829363,0.00126244,0.9941276,0.000009847673],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001361892,0.9980657,0.00008012518,0.0002504563,0.000176559,0.000005501036,0.00002398909,0.000007823121,0.001253711],"genre_scores_gemma":[0.0006120603,0.9981031,0.0001062116,0.000233222,0.0001144234,0.000004890597,0.00004160815,0.000001190375,0.0007832452],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003899614,"threshold_uncertainty_score":0.01304549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1533171886036247,"score_gpt":0.4500440351909837,"score_spread":0.296726846587359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}