{"id":"W4366603060","doi":"10.15252/emmm.202317454","title":"Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Argonne National Laboratory; Office of Science; National Cancer Institute; National Institutes of Health; Hospital for Sick Children; Deutsches Krebsforschungszentrum; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; U.S. Department of Energy","keywords":"Epitope; Plasmodium falciparum; Circumsporozoite protein; Monoclonal antibody; Biology; Linker; Virology; Conformational epitope; Antibody; Epitope mapping; Malaria vaccine; Molecular biology; C-terminus; N-terminus; Peptide sequence; Gene; Genetics; Malaria; Amino acid; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131253,0.0002739182,0.00008917713,0.0001233586,0.00009578668,0.0001497965,0.00009762403,0.0001729328,0.001747113],"category_scores_gemma":[0.0001927721,0.00007779659,0.0001570635,0.000129905,0.0001164085,0.0001040231,0.00006676273,0.000234386,0.0003914771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254342,"about_ca_system_score_gemma":0.0001541454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236776,"about_ca_topic_score_gemma":0.0006537305,"domain_scores_codex":[0.9999253,0.00001632099,0.000004037826,0.00001508903,0.00002018778,0.00001914787],"domain_scores_gemma":[0.9998925,0.00003650674,0.00001220359,0.00001088613,0.0000236269,0.00002434753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001163552,0.00002668403,0.0004787435,0.00002890411,0.000005984438,0.00004825125,0.0000154192,0.0001687736,0.9965101,0.0001124714,0.00008503344,0.002403376],"study_design_scores_gemma":[0.00002898744,0.0005805578,0.01320246,0.000007196907,0.00002171749,0.001111198,0.00002090545,0.001499965,0.9782919,0.00009140683,0.005136751,0.000007035744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902673,0.001917594,0.003905706,0.0001056247,0.00001595419,0.00002969402,0.0005436487,0.00004338461,0.003171069],"genre_scores_gemma":[0.9946241,0.0007358133,0.001738465,0.00008369201,0.0000140898,0.00002085827,0.001118224,0.00001097283,0.001653735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747113,"threshold_uncertainty_score":0.005844653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03163010775265895,"score_gpt":0.2907824790654132,"score_spread":0.2591523713127542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}