{"id":"W4366603060","doi":"10.15252/emmm.202317454","title":"Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Argonne National Laboratory; Office of Science; National Cancer Institute; National Institutes of Health; Hospital for Sick Children; Deutsches Krebsforschungszentrum; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; U.S. Department of Energy","keywords":"Epitope; Plasmodium falciparum; Circumsporozoite protein; Monoclonal antibody; Biology; Linker; Virology; Conformational epitope; Antibody; Epitope mapping; Malaria vaccine; Molecular biology; C-terminus; N-terminus; Peptide sequence; Gene; Genetics; Malaria; Amino acid; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004150618,0.0002235558,0.0005859135,0.0003983354,0.00009786039,0.00001118529,0.0001019281,0.0001017369,0.0001799388],"category_scores_gemma":[0.0004105773,0.0001625072,0.00009687213,0.0003704989,0.0005005721,0.00004863096,0.0001174953,0.0002467681,0.00002725648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002263948,"about_ca_system_score_gemma":0.0001085175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009933373,"about_ca_topic_score_gemma":0.000005008186,"domain_scores_codex":[0.9979188,0.00008442816,0.0003783173,0.0003565053,0.0008221199,0.0004397919],"domain_scores_gemma":[0.9990115,0.00003367221,0.00008202339,0.0003793395,0.0002158462,0.0002776261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002960892,0.00006163926,0.0008329368,0.0004013066,0.0002256606,0.001538592,0.0002552522,0.00001146142,0.9897054,0.003898031,0.001978318,0.0007952687],"study_design_scores_gemma":[0.01307853,0.003478812,0.07633992,0.001545733,0.0005928298,0.0006301799,0.001169431,0.002285149,0.8959221,0.001663862,0.002776591,0.0005168942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798008,0.002742021,0.0003823944,0.01187986,0.0001211312,0.0005473506,0.000006317558,0.0001064476,0.004413692],"genre_scores_gemma":[0.9975052,0.00007816932,0.00003603958,0.0006694577,0.0001418125,0.00005511851,0.00007177582,0.00003599053,0.001406429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09378337,"threshold_uncertainty_score":0.662685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03163010775265895,"score_gpt":0.2907824790654132,"score_spread":0.2591523713127542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}